Impact of donor/recipient size matching on outcomes in renal transplantation

Transplantation
R S GastonJ J Curtis

Abstract

Interest in nonimmunologic factors affecting longterm graft survival has focused on adequacy of nephron dosing. Body surface are (BSA) is a reliable surrogate for nephron mass. In a retrospective study of 378 primary recipients of paired kidneys from 189 cadaveric donors, we assessed the impact of matching donor and recipient BSA on outcome over 7 years. BSA of donors was 1.82 +/- 0.26 m2. Initially, paired recipients of kidneys from a single donor were divided into two groups. Group 1 included the recipient with the larger BSA of the pair (1.97 +/- 0.17 m2), while group 2 consisted of smaller BSA recipients (1.69 +/- 0.19 m2). Although early function was better in group 2 patients, graft survival at 1 year (77% vs. 79%) and 5 years (54% vs. 55%) was identical between groups, as were most recent serum creatinine levels (2.0 +/- 0.1 vs. 2.1 +/- 0.1 mg/dl). A second analysis divided patients with a functioning allograft at discharge from initial transplant hospitalization (n = 345) into three groups based solely on donor to recipient BSA ratio: the ratio of group A (n = 30) was < or = 0.8, that of group B (n = 255) was between 0.81 and 1.19, and that of group C (n = 51) was > or = 1.2. Graft survival and kidney function over 5 ye...Continue Reading

References

Aug 1, 1992·Journal of the American Society of Nephrology : JASN·B M BrennerE L Milford
Feb 1, 1992·The Anatomical Record·J R Nyengaard, T F Bendtsen
Dec 1, 1991·Annals of Surgery·E J SchweitzerJ S Najarian
Feb 27, 1995·Transplantation·J D PirschF O Belzer
Jul 1, 1994·Kidney International·T H Hostetter
Nov 1, 1994·The Journal of Clinical Investigation·H S MackenzieN L Tilney
May 27, 1994·Transplantation·P I TerasakiD W Gjertson
Apr 1, 1993·Transplantation·P S AlmondJ S Najarian
May 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B M Brenner, E L Milford

❮ Previous
Next ❯

Citations

Aug 11, 2001·Transplantation Proceedings·G PourmandK Nourijelyani
May 16, 2002·Transplantation Proceedings·J C C Baptista-SilvaJ O Medina-Pestana
Feb 25, 1998·Transplantation Proceedings·Y NishimuraH Uchida
Jan 5, 2000·Transplantation Proceedings·M GokhanM Haberal
Jun 26, 1999·Clinical Transplantation·M BunkeB Ketel
Nov 22, 2000·Transplantation·P D Mason
Jun 28, 2003·Transplantation·Dai D Nghiem
Jul 17, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·E ToronyiF Perner
Aug 20, 2005·Nephrology·Kirsten A ArmstrongNicole M Isbel
Jun 16, 2005·Kidney International·Simone A JoostenLeendert C Paul
Jul 15, 2005·Kidney International. Supplement·Valerie A Luyckx, Barry M Brenner
May 22, 2010·Journal of the American Society of Nephrology : JASN·Magali GiralJean Paul Soulillou
May 26, 2007·Transplantation Proceedings·M TaherimahmoudiG Pourmand
Dec 11, 2008·Pediatric Transplantation·Stefano GiulianiGiovanni Franco Zanon
Aug 13, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H TentG J Navis
Jun 4, 2015·Transplantation Proceedings·P DinisA Mota
Apr 3, 2015·International Urology and Nephrology·Jorge DiasAntónio Castro-Henriques
Mar 21, 2017·Nephron·UNKNOWN Low Birth Weight and Nephron Number Working Group
Jul 17, 2007·Pediatric Transplantation·A BasiriZ Razzaghi
Nov 26, 2004·Journal of the American Society of Nephrology : JASN·Magali GiralJean Paul Soulillou
Apr 1, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Amanda J MillerKarthik K Tennankore
Nov 5, 2019·PloS One·Flávio Vasconcelos OrdonesLuis Gustavo Modelli de Andrade
Aug 28, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Fanny LepeytreHéloïse Cardinal
Nov 16, 2017·International Urology and Nephrology·Limy WongPeter J Conlon
Jul 26, 2002·Journal of the American Society of Nephrology : JASN·Bertram L KasiskeDavid Gilbertson
Mar 27, 2001·Transplantation Proceedings·P A AndrewsC G Koffman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.