Impact of dose-dense neoadjuvant chemotherapy on pathologic response and survival for HER2-positive breast cancer patients who receive trastuzumab.

NPJ Breast Cancer
Lize WangTao Ouyang

Abstract

To compare outcomes in patients with human epidermal growth factor receptor-2 (HER2)-positive breast cancer who received either dose-dense neoadjuvant chemotherapy (NAC) with trastuzumab or standard-interval chemotherapy with trastuzumab. Patients with HER2-positive breast cancer who received NAC, including epirubicin and cyclophosphamide followed by paclitaxel with trastuzumab were included. Patients were divided into either the dose-dense or standard-interval group. We compared pathologic complete remission (pCR), distant disease-free survival (DDFS), event-free survival (EFS), and breast cancer-specific survival (BCSS) between the two groups. Two hundred (49.6%) patients received dose-dense NAC, and 203 (50.4%) received standard-interval NAC. The pCR rate was 38.4% in the dose-dense group and 29.2% in the standard-interval group (P = 0.052). In patients with lymph node (LN) metastases, the LN pCR rate was 70.9% in the dose-dense group and 56.5% in the standard-interval group (P = 0.037). After a median follow-up of 54.6 months, dose-dense chemotherapy presented an improvement on DDFS (hazard ratio [HR] = 0.49, 95% confidence interval [CI]: 0.19-1.28, EFS (HR = 0.54, 95% CI: 0.24-1.21), and BCSS (HR = 0.41, 95% CI: 0.11-1.51)...Continue Reading

References

Aug 9, 2006·Nature Clinical Practice. Oncology·Richard Simon, Larry Norton
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael UntchGottfried E Konecny
Nov 26, 2010·Journal of the National Cancer Institute·Luisa BonillaSalomon M Stemmer
Jul 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edith A PerezNorman Wolmark
Oct 14, 2011·The New England Journal of Medicine·Dennis SlamonUNKNOWN Breast Cancer International Research Group
Apr 18, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gunter von MinckwitzSibylle Loibl
Oct 9, 2013·JAMA : the Journal of the American Medical Association·Judy C BougheyUNKNOWN Alliance for Clinical Trials in Oncology
Oct 22, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edith A PerezNorman Wolmark
Mar 3, 2015·The Breast : Official Journal of the European Society of Mastology·Yeon Hee ParkYoung-Hyuck Im
Nov 9, 2016·JAMA : the Journal of the American Medical Association·Theodoros FoukakisUNKNOWN Swedish Breast Cancer Group (SweBCG), the German Breast Group (GBG), and the Austrian Breast & Colorectal Cancer Study Group
May 2, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V MöbusUNKNOWN German Breast Group (GBG), the AGO Breast Study Group (AGO-B) and NOGGO Study Groups
Jun 6, 2017·The New England Journal of Medicine·Gunter von MinckwitzUNKNOWN APHINITY Steering Committee and Investigators
Oct 27, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V MöbusUNKNOWN AGO Breast Study Group (AGO-B)
Dec 6, 2018·The New England Journal of Medicine·Gunter von MinckwitzUNKNOWN KATHERINE Investigators
Nov 15, 2019·International Journal of Cancer. Journal International Du Cancer·Matteo LambertiniUNKNOWN GIM2 investigators
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H J BursteinUNKNOWN Members of the St. Gallen International Consensus Panel on the Primary Therapy of Early Breast Cancer 2019

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Matteo LambertiniMIG and GIM study groups
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Chau DangC Hudis
Gan to kagaku ryoho. Cancer & chemotherapy
Noriyuki Katsumata
Current Opinion in Oncology
Eva BlondeauxLucia Del Mastro
© 2021 Meta ULC. All rights reserved