PMID: 11339754May 8, 2001Paper

Impact of dose-distribution uncertainties on rectal ntcp modeling. II: Uncertainty implications

Medical Physics
J D Fenwick

Abstract

A trial of nonescalated conformal versus conventional radiotherapy treatment of prostate cancer has been carried out at the Royal Marsden NHS Trust (RMH) and Institute of Cancer Research (ICR), demonstrating a significant reduction in the rate of rectal bleeding reported for patients treated using the conformal technique. The rate of bleeding has been shown to fall significantly as the extent of rectal wall receiving a planned dose-level in excess of 57 Gy is reduced. Dose-distributions delivered to the rectal wall over the course of radiotherapy treatment inevitably differ from planned distributions. In a previous paper estimates were obtained of the uncertainties in some planned rectal dose-distribution parameters generated by patient setup error, rectal wall movement and the variable degree of rectal wall distension. Here these uncertainties are combined to obtain estimates of the total planning uncertainties in rectal dose-distribution parameters thought likely, on the basis of mechanistic biological modeling, to correlate strongly with the complication rate. Working from these totaled uncertainty values, together with values of patient-to-patient and technique-to-technique differences in planned dose-distribution parameter...Continue Reading

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Citations

Jul 27, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Claudio FiorinoCesare Cozzarini
Sep 5, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Claudio FiorinoAnna Piazzolla
Sep 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Franca FoppianoUNKNOWN AIRO National Working Group on Prostate Radiotherapy
Oct 25, 2003·International Journal of Radiation Oncology, Biology, Physics·Claudio FiorinoRiccardo Valdagni
Nov 25, 2003·International Journal of Radiation Oncology, Biology, Physics·Raymond MiralbellMichel Rouzaud
Apr 24, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Florian BuettnerMike Partridge
Sep 1, 2004·International Journal of Radiation Oncology, Biology, Physics·Peter W M ChungCharles N Catton
Mar 31, 2004·International Journal of Radiation Oncology, Biology, Physics·Rex CheungDeborah Kuban
Oct 19, 2004·Medical Physics·Jun Lian, Lei Xing
Mar 10, 2011·Physics in Medicine and Biology·Florian BuettnerMike Partridge

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