Impact of Early Initiated Everolimus on the Recurrence of Hepatocellular Carcinoma After Liver Transplantation

Transplantation
Manuel Rodríguez-PerálvarezManuel De la Mata

Abstract

Many centers implement everolimus-based immunosuppression in liver transplant patients with hepatocellular carcinoma. We aimed to explore the potential impact of early initiated everolimus on tumor recurrence after liver transplantation. This study included 192 patients with hepatocellular carcinoma undergoing liver transplantation among who 64 individuals were prospectively enrolled (2012-2015) and received early initiated everolimus (ie, started between postoperative day 15 to 21), whereas the remaining 128 patients acted as historical controls without everolimus. Propensity score matching was performed to ensure comparability. Multivariate Cox regression and competing risks analysis were used to control for potential confounders. Patients with and without everolimus were comparable in terms of number of nodules (P = 0.37), total tumor diameter (P = 0.44), Milan criteria fulfillment (P = 0.56), and histological differentiation (P = 0.61), but there were increased microvascular invasion rates in the everolimus group (26.5% vs 13.3%; P = 0.026). Tumor recurrence rates were similar with and without everolimus (10.9% vs 9.9% at 36 months respectively; P = 0.18). After controlling for microvascular invasion among other potential c...Continue Reading

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Citations

Dec 29, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Umberto CilloErida Nure
Jul 31, 2019·Alimentary Pharmacology & Therapeutics·Manuel Rodríguez-PerálvarezManuel de la Mata
Feb 20, 2020·International Journal of Molecular Sciences·Gustavo FerrínManuel De la Mata
Apr 26, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sotiria BedreliKerstin Herzer
Jan 18, 2019·International Journal of Molecular Sciences·Marta GuerreroManuel de la Mata
Jan 30, 2021·Frontiers in Cell and Developmental Biology·Marta CollettiFrancesca Nazio
Nov 14, 2020·International Journal of Molecular Sciences·Shintaro YagiShinji Uemoto
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Dec 18, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Xiangyu YanJun Liu

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