Impact of Early Leukocytosis and Elevated High-Sensitivity C-Reactive Protein on Delayed Cerebral Ischemia and Neurologic Outcome After Subarachnoid Hemorrhage

World Neurosurgery
Anirudh SrinivasanSivashanmugam Dhandapani

Abstract

The role of inflammatory response in the pathophysiology of subarachnoid hemorrhage (SAH) is being increasingly recognized. This study analyzed the impact of cellular and biochemical markers of early inflammatory response to ictus on outcome after SAH. Patients with SAH were prospectively studied for markers of early cellular, biochemical, and cytotoxic inflammatory response, including total leukocyte count (TLC), high-sensitivity C-reactive protein (hs-CRP), and lactate dehydrogenase. The relationship of these markers to delayed cerebral ischemia (DCI), new infarct, and Glasgow Outcome Scale (GOS) score at 3 months was studied. The study comprised 246 patients. Of patients, 94 who developed DCI had a significantly higher TLC [± SD] (11.2 × 10(3)/mm(3) [± 4.0] vs. 9.4 × 10(3)/mm(3) [± 2.9], P = 0.001) and 62 with new infarct had significantly higher TLC (11.0 × 10(3)/mm(3) [± 3.6] vs. 9.8 × 10(3)/mm(3) [± 3.4], P = 0.05). GOS score had a significant inverse relationship to TLC at admission. The mean TLC [± SD] was 12.7 × 10(3)/mm(3) [± 4.2], 11.7 × 10(3)/mm(3) [± 3.1], 10.2 × 10(3)/mm(3) [± 3.4], and 9.3 × 10(3)/mm(3) [± 2.8] among patients with GOS scores of 1, 3, 4, and 5 (P < 0.001). hs-CRP showed a trend of an inverse relat...Continue Reading

References

Nov 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·G M TeasdaleJ C De Villiers
Mar 1, 1974·Brain : a Journal of Neurology·G Neil-Dwyer, J Cruickshank
Feb 1, 1984·Surgical Neurology·D Parkinson, S Stephensen
Aug 22, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·B G Nordestgaard, J Zacho
Dec 3, 2011·Acta neurochirurgica·Seppo JuvelaJari Siironen
May 29, 2012·Asian Journal of Neurosurgery·S S DhandapaniA K Mahapatra
Aug 7, 2012·Journal of Neurosciences in Rural Practice·Ss DhandapaniAk Mahapatra
Nov 20, 2013·Journal of Neurosciences in Rural Practice·Ashish AggarwalAshwani Kumar Sachdeva
Jan 15, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Sivashanmugam DhandapaniLakshman Das
Feb 7, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Caron M HongJ Marc Simard

❮ Previous
Next ❯

Citations

Jul 1, 2017·British Journal of Neurosurgery·Ankur KapoorKanchan K Mukherjee
Oct 11, 2017·Journal of Neurosurgical Anesthesiology·Vito FontanaFabio S Taccone
Jul 26, 2017·Neurosurgical Review·Sivashanmugam DhandapaniSunil K Gupta
Apr 10, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Aisha R SaandSherry H-Y Chou
Aug 15, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A A KalinkinV V Krylov
Apr 2, 2020·The Journal of International Medical Research·Huifang DaiLielie Zhu
Sep 30, 2020·Acta Neurologica Scandinavica·Sandra Bjerkne WennebergLinda Block
Feb 18, 2021·Reviews in the Neurosciences·Alcivan Batista de Morais FilhoFausto Pierdoná Guzen
Aug 13, 2021·Frontiers in Neurology·Aaron M GusdonHuimahn Alex Choi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.