Impact of epidermal desquamation on tissue stores of iron.

Journal of Dermatological Science
Leonard M MilstoneJing Zhou

Abstract

Although several billion corneocytes are shed from human skin daily, metabolic studies from 50 years ago led to the conclusion that corneocyte desquamation had no measurable impact on systemic protein or iron status in humans. To measure iron content of internal organs after introducing local genetic changes in epidermis that alter iron metabolism in skin. Iron was measured in tissues and blood from groups of animals 7 weeks after weaning in three different mouse models expressing a transgene in epidermis: a hyperproliferation model in which the HPV16 E7 gene causes a 3-fold increase in epidermal turnover; an epidermal iron sink model in which overexpression of the transferrin receptor causes a 3-4 fold increase of iron in epidermis; a systemic hemochromatosis knockout model that has been crossed with the epidermal iron sink model. In the hemochromatosis model with the iron sink transgene in epidermis, there was a statistically significant reduction in non-heme iron in serum and in the liver and kidney. In all models there was a statistically significant reduction in non-heme iron in the kidney. Local changes in iron metabolism in epidermis can have a measurable impact on systemic iron metabolism. By implication, disruptions in...Continue Reading

References

Nov 1, 1976·Scandinavian Journal of Clinical and Laboratory Investigation·L Molin, P O Wester
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R M GrossmanA B Gottlieb
Nov 1, 1968·Archives of Dermatology·J Marks, S Shuster
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·J N FederR C Schatzman
Mar 23, 1999·Acta Dermato-venereologica·B ForslindJ Pallon
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·R E FlemingW S Sly
Mar 20, 2002·The British Journal of Dermatology·A GeusauM McLachlan
Nov 1, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kwo-yih YehJonathan Glass
Nov 16, 2004·Journal of Dermatological Science·Leonard M Milstone
Dec 16, 2005·The Journal of Investigative Dermatology·Brian D AdamsLeonard M Milstone
Jan 21, 2006·The Journal of Investigative Dermatology·Leonard M MilstoneJoshua Shofner
Mar 5, 2008·Cell Metabolism·Paul J SchmidtNancy C Andrews
Jun 13, 2009·The Journal of Investigative Dermatology·Tamar Nijsten, Marlies Wakkee
Jul 1, 2009·Experimental Gerontology·Paul HahnJoshua L Dunaief

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Citations

Oct 9, 2015·The American Journal of Chinese Medicine·Wen-Jun ZhangChun-Su Yuan
Jul 30, 2014·Frontiers in Pharmacology·Josephine A WrightSurjit K S Srai
Jun 9, 2016·Pharmaceutical Development and Technology·Jiaoying WangChunsu Yuan

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