Impact of ESR1 Gene Polymorphisms on Migraine Susceptibility: A Meta-Analysis.

Medicine
Li LiShengyuan Yu

Abstract

An increasing number of studies have explored genetic associations between the functionally important polymorphisms in estrogen receptor 1 (ESR1) gene and migraine susceptibility. The previously reported associations have nevertheless been inconsistent.The present work incorporating the published data derived from 8 publications was performed to assess the impact of these polymorphisms on incident migraine. Strength of the genetic risk was estimated by means of an odds ratio along with the 95% confidence interval (OR and 95% CI).From the results, we found individuals who harbored the 325-GG genotype, compared with those harboring the CC genotype or CG and CC combined genotypes, had almost 50% greater risk of migraine. The same genetic models showed notable associations in subgroups of Caucasians and migraine with aura (MA). For 594G>A, a moderately increased risk of migraine was seen under AG versus GG. The AA + AG versus GG model, however, showed a borderline association with migraine. Subgroup analyses according to ethnicity and subtype of migraine provided statistical evidence of significantly increased risk of migraine in Caucasians and of a marginal association with MA, respectively. Both 325C>G and 594G>A polymorphisms sh...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jun 1, 1994·Headache·R B LiptonW F Stewart
Feb 1, 1997·Neurologic Clinics·E A MacGregor
Aug 8, 1997·The Journal of Biological Chemistry·S M CowleyM G Parker
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Feb 12, 1998·Annals of Internal Medicine·J LauC H Schmid
Sep 28, 1999·Current Opinion in Neurology·E E KorsM D Ferrari
Feb 19, 2000·Annals of Medicine·N P Davies, M G Hanna
Mar 29, 2000·The Journal of Biological Chemistry·R L KrausJ Striessnig
May 19, 2000·Cephalalgia : an International Journal of Headache·P Montagna
Sep 21, 2000·Cephalalgia : an International Journal of Headache·S D Silberstein, G R Merriam
Apr 17, 2001·Cephalalgia : an International Journal of Headache·K HagenG Bovim
Sep 25, 2001·Journal of Applied Physiology·E R Levin
Jul 10, 2003·Lancet Neurology·Anne DucrosMarie-Germaine Bousser
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Feb 26, 2004·Cephalalgia : an International Journal of Headache·UNKNOWN Headache Classification Subcommittee of the International Headache Society
Sep 6, 2005·Genes & Development·Mi Young KimW Lee Kraus
Dec 20, 2005·Neuroreport·Agustín OterinoPedro Muñoz
Jan 30, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R CorominasA Macaya
Mar 26, 2009·British Journal of Cancer·K EinarsdóttirK Humphreys
Sep 18, 2009·Breast Cancer Research and Treatment·Ni LiMin Dai
Jan 9, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jennifer A DohertyUNKNOWN Ovarian Cancer Association Consortium (OCAC)
Oct 21, 2010·Cephalalgia : an International Journal of Headache·Markus SchürksTobias Kurth
Oct 21, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Takahiro IizukaFumihiko Sakai
Nov 16, 2011·Headache·Oriel CarreñoAlfons Macaya
Sep 11, 2012·The Open Neurology Journal·Vincenzo PizzaAnna Capasso
May 16, 2013·Cephalalgia : an International Journal of Headache·Astrid J Rodriguez-AcevedoLyn R Griffiths

❮ Previous
Next ❯

Citations

Oct 26, 2016·Journal of Neurology·Xingkai AnHongli Qu
Feb 10, 2017·Headache·Gretchen E Tietjen, Stuart A Collins
Mar 9, 2018·Critical Reviews in Food Science and Nutrition·Maria Laura De MarchisRaffaele Palmirotta
Dec 1, 2018·The Journal of Headache and Pain·Zoë DelaruelleUNKNOWN European Headache Federation School of Advanced Studies (EHF-SAS)
Jun 13, 2018·International Journal of Molecular Sciences·Nebojsa Nick KnezevicKenneth D Candido
Feb 13, 2020·The Journal of Headache and Pain·Yating ZhaoXu Liu
Nov 17, 2020·Frontiers in Neurology·Linda Al-HassanyJessica L Rohmann
Apr 30, 2020·ACS Chemical Neuroscience·Swapnil RautPallab Bhattacharya

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.