Impact of Estrogen on the Relationship Between Obesity and Renal Cell Carcinoma Risk in Women

EBioMedicine
Lijiang SunGuiming Zhang

Abstract

The relationship between obesity and renal cell carcinoma (RCC) has been widely investigated. However, the effect of estrogen on this relationship in female RCC patients has not been evaluated. We conducted a case-control study to investigate the role of estrogen as a potential modifier of the association between obesity and RCC risk in Chinese women. A total of 497 consecutive female patients with pathologically confirmed RCC, including 364 clear cell RCC (ccRCC), were enrolled. Age-matched controls were selected from cancer-free females seeking physical examination in our institution. Estrogen receptor-β (ER-β) and insulin-like growth factor (IGF)-1 receptor (IGF-1R) expression levels were detected in RCC tissues. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated by logistic regression models. We observed a positive association between overweight and RCC risk in pre-menopausal but not post-menopausal women. Similar association was also observed between overweight and ccRCC risk. Overweight pre-menopausal women had an increased risk of RCC (OR: 1.67, 95%CI: 1.01-2.76), as well as an increased risk of ccRCC (OR: 1.73, 95%CI: 1.02-2.99), after adjusting for potential confounders. IGF-1R expression levels we...Continue Reading

Citations

Mar 24, 2020·Pharmaceutical Biology·Lili DaiPeizheng Lin
Jul 17, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Xiaojun ZhangAnguo Wang
Oct 6, 2020·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Xiaojuan ShaoKaijun Liu
Feb 1, 2021·Stem Cell Reviews and Reports·Khyati RainaRajkumar P Thummer

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BETA
biopsy
hormone replacement therapy

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STATA

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