Impact of exogenous gonadotropin stimulation on circulatory and follicular fluid cytokine profiles

International Journal of Reproductive Medicine
N Ellissa BaskindVinay Sharma

Abstract

Background. The natural cycle is the prototype to which we aspire to emulate in assisted reproduction techniques. Increasing evidence is emerging that controlled ovarian hyperstimulation (COH) with exogenous gonadotropins may be detrimental to oogenesis, embryo quality, and endometrial receptivity. This research aimed at assessing the impact of COH on the intrafollicular milieu by comparing follicular fluid (FF) cytokine profiles during stimulated in vitro fertilization (IVF) and modified natural cycle (MNC) IVF. Methods. Ten women undergoing COH IVF and 10 matched women undergoing MNC IVF were recruited for this pilot study. 40 FF cytokine concentrations from individual follicles and plasma were measured by fluid-phase multiplex immunoassay. Demographic/cycle/cytokine data were compared and correlations between cytokines were computed. Results. No significant differences were found between COH and MNC groups for patient and cycle demographics, including outcome. Overall mean FF cytokine levels were higher in the MNC group for 29/40 cytokines, significantly so for leukaemia inhibitory factor and stromal cell-derived factor-1α. Furthermore, FF MNC cytokine correlations were significantly stronger than for COH data. Conclusions. ...Continue Reading

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Citations

May 3, 2018·The Journal of Clinical Endocrinology and Metabolism·Daimin WeiZi-Jiang Chen
Jun 27, 2019·Reproductive Biology and Endocrinology : RB&E·Cui-Ling LuJie Qiao
Apr 10, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Francesca CirilloMaria E Street
Nov 29, 2020·The Journal of Clinical Endocrinology and Metabolism·Marie-Pierre PiccinniRenato Seracchioli

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
sedation
Assay
enzyme-linked immunosorbent assay

Software Mentioned

R Foundation for Statistical
SE
BioPlex
R
Stata

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