Impact of Exposure to Antibiotics During Pregnancy and Infancy on Childhood Obesity: A Systematic Review and Meta-Analysis

Obesity
Shengrong WanYong Xu

Abstract

This study aimed to investigate whether antibiotic exposure during pregnancy and infancy was associated with childhood overweight or obesity. PubMed, Embase, and Cochrane Library databases were searched from the inception date to April 18, 2019, to identify observational studies that investigated the association between antibiotic exposure during pregnancy and infancy and childhood overweight or obesity. After study selection and data extraction, the meta-analysis was conducted using Stata software version 12.0 (StataCorp LP, College Station, Texas). The evaluation of the methodological quality was carried out by AMSTAR 2 (Bruyère Research Institute, Ottawa, Ontario, Canada). A total of 23 observational studies involving 1,253,035 participants were included. The meta-analysis showed that prenatal exposure to antibiotics was not significantly associated with childhood overweight or obesity, whereas an increased risk of overweight or obesity was seen in subgroup analysis of the second trimester (risk ratio = 1.13; 95% CI: 1.06-1.22; P = 0.001). In contrast, antibiotic exposure during infancy could increase the risk of childhood overweight or obesity (risk ratio = 1.14; 95% CI: 1.06-1.23; P = 0.001). This meta-analysis found that ...Continue Reading

References

Dec 10, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A E CzeizelJ Olsen
Jun 5, 2004·Early Human Development·Mehmet Ali MalasOzden Candir
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Mar 1, 2006·International Journal of Clinical Pharmacology and Therapeutics·G M Pacifici
May 13, 2006·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jun-Yang ChunGideon Koren
Dec 22, 2006·Nature·Ruth E LeyJeffrey I Gordon
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Mar 11, 2008·The American Journal of Clinical Nutrition·Marko KalliomäkiErika Isolauri
Mar 10, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T A AjslevT Jess
Aug 10, 2011·BMJ : British Medical Journal·Douglas G Altman, J Martin Bland
Feb 7, 2012·Environmental Health Perspectives·Thorhallur I HalldorssonSjurdur F Olsen
Aug 22, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L TrasandeM J Blaser
Jun 4, 2013·Acta Paediatrica·Rinki MurphyUNKNOWN ABC study group
Nov 22, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R MurphyUNKNOWN ISAAC Phase Three Study Group
May 23, 2014·Science Translational Medicine·Kjersti AagaardJames Versalovic
Jul 12, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M B AzadA L Kozyrskyj
Sep 30, 2014·JAMA Pediatrics·L Charles BaileyPatricia A DeRusso
Oct 10, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·N T MuellerA Rundle
Dec 10, 2014·Nature Reviews. Endocrinology·Laura M Cox, Martin J Blaser
Jul 17, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A MorV Ehrenstein
Mar 24, 2016·JAMA : the Journal of the American Medical Association·Jeffrey S GerberTheoklis E Zaoutis
Jul 13, 2016·The Journal of Pediatrics·Catherine A MbakwaIlja C W Arts
Nov 7, 2016·The Lancet. Diabetes & Endocrinology·De-Kun LiRoxana Odouli
Feb 7, 2017·Childhood Obesity·Annette P VilleJanet M Wojcicki
Jun 13, 2017·The New England Journal of Medicine·UNKNOWN GBD 2015 Obesity CollaboratorsChristopher J L Murray
Sep 20, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A E Cassidy-BushrowG Wegienka
Jan 24, 2018·Diabetes, Obesity & Metabolism·Sara H RasmussenKristine H Allin
Jun 13, 2018·American Journal of Epidemiology·Bin WangJun Zhang
Jul 24, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S A MillerM Oremus
Nov 2, 2018·Pediatrics·Jason P BlockUNKNOWN PCORnet Antibiotics and Childhood Growth Study Group
Jan 18, 2019·BMC Pediatrics·Elizabeth E Dawson-Hahn, Kyung E Rhee
Jan 24, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·William J HeermanUNKNOWN PCORnet Antibiotics and Childhood Growth Study Group

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Citations

Jul 4, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Peng JiaYaogang Wang
Dec 17, 2020·Evolution, Medicine, and Public Health·Semeh Bejaoui, Michael Poulsen
Jul 15, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carla Sosa AlvaradoCatherine B Chan
Jul 31, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Xin MengZuxun Lu

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