Impact of Ezetimibe on the Rate of Cardiovascular-Related Hospitalizations and Associated Costs Among Patients With a Recent Acute Coronary Syndrome: Results From the IMPROVE-IT Trial (Improved Reduction of Outcomes: Vytorin Efficacy International Trial)

Circulation. Cardiovascular Quality and Outcomes
Yashashwi PokharelElizabeth A Magnuson

Abstract

Ezetimibe, when added to simvastatin therapy, reduces cardiovascular events after recent acute coronary syndrome. However, the impact of ezetimibe on cardiovascular-related hospitalizations and associated costs is unknown. We used patient-level data from the IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial) to examine the impact of simvastatin-ezetimibe versus simvastatin-placebo on cardiovascular-related hospitalizations and related costs (excluding drug costs) over 7 years follow-up. Medicare Severity-Diagnosis Related Groups were assigned to all cardiovascular hospitalizations. Hospital costs were estimated using Medicare reimbursement rates for 2013. Associated physician costs were estimated as a percentage of hospital costs. The impact of treatment assignment on hospitalization rates and costs was estimated using Poisson and linear regression, respectively. There was a significantly lower cardiovascular hospitalization rate with ezetimibe compared with placebo (risk ratio, 0.95; 95% confidence interval, 0.90-0.99; P=0.031), mainly attributable to fewer hospitalizations for percutaneous coronary intervention, angina, and stroke. Consequently, cardiovascular-related hospitalization costs over ...Continue Reading

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Citations

Mar 25, 2019·The Journal of Clinical Endocrinology and Metabolism·Derek LeRoithAlan J Sinclair
Aug 22, 2020·Journal of Lipid and Atherosclerosis·Jah Yeon Choi, Jin Oh Na
Sep 11, 2019·European Heart Journal·François MachUNKNOWN ESC Scientific Document Group
Oct 9, 2019·Atherosclerosis·UNKNOWN Authors/Task Force MembersUNKNOWN ESC National Cardiac Societies

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