Impact of family history on relations between insulin resistance, LDL cholesterol and carotid IMT in healthy adults

Heart
C AnderwaldRISC Investigators

Abstract

Insulin resistance (IR) is implicated as an independent risk factor for vascular disease. The aim of this study was to assess the impact of family history (FH) of type 2 diabetes (T2DM) and/or cardiovascular disease (CVD) on the associations between IR, low-density-lipoprotein cholesterol (LDL-C) and subclinical atherosclerosis (common and internal carotid artery intima media thickness (IMT)) in healthy European adults. Participants (n=1048) in the Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) study were grouped according to family history of: (i) type 2 diabetes (FH-T2DM); (ii) cardiovascular disease (FH-CVD); (iii) both (FH-BOTH); or (iv) neither (CON). Insulin resistance (M-value, hyperinsulinaemic euglycaemic clamp), LDL-C and IMT were examined in relation to FH in all available participants, and then within subcohorts (highest quintiles) with higher LDL-C (>3.5 mmol/l (>135 mg/dl), n=252) or greater IR (M-value<5 mg/min/kg, n=299). Carotid IMTs were comparable across the four FH groups, but insulin sensitivity (M-value) was lower (p<0.01) in FH-T2DM (6.1+/-2.6 mg/min/kg than in either CON (6.9+/-2.9 mg/min/kg) or FH-CVD (7.1+/-2.7 mg/min/kg). Within the highest LDL-C quintile, those with FH-CVD...Continue Reading

Citations

Oct 1, 2010·Internal and Emergency Medicine·Giuseppe Novelli
Nov 29, 2011·Diabetes Research and Clinical Practice·Kara M GoodrichSteven N Blair
Apr 24, 2012·Journal of Diabetes and Its Complications·Michel P HermansMichel F Rousseau
Oct 13, 2015·Diabetes & Metabolism·G-M ParkJ-Y Park
May 24, 2011·Diabetes Care·Christian AnderwaldAlexandra Kautzky-Willer
Nov 27, 2019·Molecular Neuropsychiatry·Christopher A Ross, Russell L Margolis

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