Impact of fetal growth and preterm birth on the retinal microvasculature in mid-adulthood

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Sultana Monira HussainRobyn J Tapp

Abstract

We hypothesized that preterm birth and being born SGA would be associated with changes in retinal microvascular architecture and that these changes would be more marked among those born preterm. We further hypothesized that these microvascular changes would correlate with early markers of CVD in mid-adulthood. The Cardiovascular Risk in Young Finns Study included randomly selected children from 5 Finnish University cities. Retinal microvascular architecture of participants born preterm, born at term and SGA and a control group born at term and AGA were compared (aged 34-49 years). In participants born preterm, arteriolar tortuosity (×10(2)) was higher-means (standard error), 0.06 (0.01) versus 0.04 (0.01), p = 0.001, arteriolar length (pixels) were greater-644.9 (35.9) versus 591.7 (33.5), p = 0.007 and arteriolar diameters (pixels) were narrower-19.9 (0.4) versus 20.3 (0.3), p = 0.034 compared to participants born AGA, after adjustment. In participants born SGA, only arteriolar tortuosity was higher-0.05 (0.01) versus 0.04 (0.01), p = 0.074 compared to participants born AGA. This study demonstrated that being born SGA and in particular preterm birth are associated with changes in retinal microvascular architecture. The prenata...Continue Reading

References

Feb 12, 1998·Journal of Hypertension·N ChapmanS Thom
Jul 23, 1999·BMJ : British Medical Journal·A LucasT J Cole
May 27, 2003·Diabetes Care·Robyn J TappUNKNOWN AusDiab Study Group
Nov 6, 2003·JAMA : the Journal of the American Medical Association·Olli T RaitakariJorma S A Viikari
Sep 18, 2004·BMJ : British Medical Journal·Janet Tucker, William McGuire
Dec 29, 2005·Hypertension·M Kamran IkramPaulus T V M de Jong
Mar 21, 2007·Hypertension·Paul MitchellTien Y Wong
Feb 12, 2008·International Journal of Epidemiology·Olli T RaitakariJorma S A Viikari
Feb 21, 2008·Archives of Disease in Childhood. Fetal and Neonatal Edition·M J StarkI M R Wright
May 13, 2008·American Journal of Epidemiology·Jie Jin WangPaul Mitchell
Jul 16, 2008·Circulation·Paul MitchellTien Y Wong
Oct 8, 2009·Circulation. Cardiovascular Imaging·Gerald LiewTien Y Wong
Nov 1, 2011·Microvascular Research·Martin RittRoland E Schmieder
Dec 8, 2011·Clinical Endocrinology·Alejandro Martinez-AguayoCarlos Fardella
Jan 10, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Paula KestiläOlli T Raitakari
Mar 23, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Robyn J TappAlun D Hughes

❮ Previous
Next ❯

Citations

May 7, 2016·Clinical & Experimental Ophthalmology·Alexander R NewmanRobert J Casson
Jan 8, 2018·Journal of the American Heart Association·Robyn J TappOlli T Raitakari
Aug 5, 2020·Journal of the American Heart Association·Fang-Fei WeiJan A Staessen
Apr 25, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Ailee R JonesVicki L Clifton
Oct 9, 2020·Journal of Developmental Origins of Health and Disease·Prabha H AndraweeraZohra S Lassi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.