Impact of Fibrotic Tissue on Shear Wave Velocity in Thyroid: An Ex Vivo Study with Fresh Thyroid Specimens

BioMed Research International
Takahiro FukuharaHiromi Takeuchi

Abstract

We sought to elucidate the correlation between shear wave velocity (SWV) and fibrosis in thyroid by precisely assessing pathological structures inside 5 × 5 mm(2) regions of interest (ROIs) of resected specimens, under conditions that excluded physical artifacts. The materials were unselected thyroid and lymph node specimens resected during thyroid surgery. Immediately after surgery, fresh unfixed thyroid and metastatic lymph node specimens were suspended in gel phantoms, and SWV was measured. Upon pathological examination of each specimen, the extent of fibrosis was graded as none, moderate, or severe. A total of 109 specimens were evaluated: 15 normal thyroid, 16 autoimmune thyroiditis, 40 malignant nodules, 19 benign thyroid nodules, and 19 metastatic lymph nodes. When all specimens were classified according to the degree of fibrosis determined by pathological imaging, the mean SWV was 1.49 ± 0.39 m/s for no fibrosis, 2.13 ± 0.66 m/s for moderate fibrosis, and 2.68 ± 0.82 m/s for severe fibrosis. The SWVs of samples with moderate and severe fibrosis were significantly higher than those of samples without fibrosis. The results of this study demonstrate that fibrosis plays an important role in determining stiffness, as measure...Continue Reading

References

Dec 31, 2003·Ultrasound in Medicine & Biology·Kathryn NightingaleGregg Trahey
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May 29, 2014·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Angela Cepero CalveteAntonio Rios Zambudio
Dec 24, 2014·European Journal of Radiology·Ah Young ParkCheong Soo Park
Jun 10, 2015·Ultrasound in Medicine & Biology·Takahiro FukuharaHiroya Kitano
Aug 11, 2015·Journal of Thyroid Research·Takahiro FukuharaHiroya Kitano
Sep 8, 2015·Medical Ultrasonography·Koray HekimogluCanan Yazici
Oct 1, 2013·Journal of Medical Ultrasonics·Masatoshi KudoTakashi Kumada

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Citations

Aug 25, 2016·Insights Into Imaging·Costanza BrunoRoberto Pozzi Mucelli
Feb 27, 2018·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Lei HuXinshu Zhang
May 16, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Lei HuWen Zhong
Sep 7, 2018·Laryngoscope Investigative Otolaryngology·Takahiro FukuharaHiromi Takeuchi
Jan 27, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Yu-Chun YehLi-Jen Liao

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Methods Mentioned

BETA
biopsy

Software Mentioned

ImageJ
SPSS

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