Impact of frailty on outcomes in elderly patients with acute myocardial infarction who undergo percutaneous coronary intervention.

European Heart Journal. Quality of Care & Clinical Outcomes
Kensaku NishihiraYoshisato Shibata

Abstract

Frailty is characterized by reduced biological reserves and weakened resistance to stressors, and is common in older adults. This study evaluated the prognostic implications of frailty at hospitalization in elderly patients with acute myocardial infarction (AMI) who undergo percutaneous coronary intervention (PCI). We prospectively analysed 546 AMI patients aged ≥80 years undergoing PCI from 2009 to 2017. Frailty was classified based on impairment in walking (unassisted, assisted, and wheelchair/non-ambulatory), cognition (normal, mildly impaired, moderately to severely impaired), and basic activities of daily living. Impairment in each domain was scored as 0, 1, or 2, and patients were categorized into the following three groups based on total score: no frailty (0), mild frailty (1-2), moderate-to-severe frailty (≥3). The median follow-up period was 589 days. Of the 546 patients, 27.8% were frail (mild or moderate-to-severe), and this proportion significantly increased to 35.5% at discharge (P < 0.001). Compared to non-frail patients, frail patients were older, less likely to be male, and had a higher rate of advanced Killip class. Major bleeding (no frailty, 9.6%; mild frailty, 16.9%; moderate-to-severe frailty, 31.8%; P < 0....Continue Reading

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Citations

Apr 24, 2020·European Heart Journal. Acute Cardiovascular Care·Kensaku NishihiraYoshisato Shibata
Oct 16, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshihiro UchikadoMitsuru Ohishi
Oct 7, 2021·ESC Heart Failure·Goro YoshiokaKoichi Node
Oct 15, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Kensaku Nishihira, Yoshisato Shibata

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