Impact of free hydroxylated and methyl-branched fatty acids on the organization of lipid membranes

Chemistry and Physics of Lipids
Ramona JenskeWalter Vetter

Abstract

Differential scanning calorimetry (DSC) has been applied to study the effect of free hydroxylated and methyl-branched fatty acids on the physico-chemical properties of lipid membranes. First, the impact of free hydroxy fatty acids (HFAs) on dimyristoylphosphatidylcholine (DMPC) model membranes was monitored only as a function of chain length and position of the attached hydroxyl group. Second, racemic vs. enantiopure anteiso fatty acids (AFAs) and HFAs were investigated to address the question of which role does a fatty acid's chirality play on its membrane pertubing effect. The DSC thermograms revealed that the main gel to liquid-crystalline phase transition of the DMPC bilayers which results in a disordering effect of the lipid hydrocarbon chains was affected in different ways depending on the nature of the incorporated fatty acid. Long-chain 2- and 3-HFAs stabilized the gel phase by reducing the phase transition temperature (T(m)), whereas short-chain HFAs and long-chain HFAs with the hydroxy group remote from the head group stabilized the more disordered liquid-crystalline state. Additionally, we observed that enantiopure (S)-14-methylhexadecanoic acid ((S)-a17:0) and (R)-2-hydroxy octadecanoic acid and the corresponding ra...Continue Reading

References

Nov 18, 1980·Biochimica Et Biophysica Acta·H HauserD E Bowyer
May 23, 2001·Archives of Biochemistry and Biophysics·M BohnS Lüthje
Jan 4, 2003·Hypertension·Pablo V EscribáValentina Ruiz-Gutiérrez
Dec 10, 2003·Hypertension·Regina AlemanyPablo V Escribá
Sep 17, 2004·Molecular Membrane Biology·Francisca BarcelóPablo V Escribá
Dec 2, 2005·Nature·Donald M Engelman
Feb 10, 2006·Colloids and Surfaces. B, Biointerfaces·Madeleine L RogersonPeter Walde
Oct 18, 2006·Physical Chemistry Chemical Physics : PCCP·Fredrick LindströmGerhard Gröbner
May 19, 2007·Analytical Chemistry·Saskia ThurnhoferWalter Vetter

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Citations

Jun 24, 2014·Chemistry and Physics of Lipids·Józef KulaKornelia Ciolak
Nov 8, 2014·The Journal of Physical Chemistry. B·David PogerAlan E Mark
Sep 3, 2011·The Journal of Physical Chemistry. B·Javier CerezoJosé Pedro Cerón-Carrasco
Feb 5, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Alena KhmelinskaiaPablo V Escribá
Mar 3, 2021·ACS Biomaterials Science & Engineering·Junli ZhangZhenzhong Zhang
Dec 19, 2008·Journal of Agricultural and Food Chemistry·Ramona Jenske, Walter Vetter

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