Impact of freezing on bone graft incorporation biomechanical evaluations in rats

Clinical Biomechanics
Olav Reikerås

Abstract

With an increasing clinical application of grafting for bone reconstruction, it is important to understand the physiological and biological events of graft incorporation. In this study, we have investigated the impact of deep freezing on the biopotency for incorporation of bone grafts. Fresh and deep-frozen autogenous bone grafts were implanted in an 8-mm segmental defect in the tibia. The construct was stabilized with intramedullary nailing. Incorporation of the graft was assessed with use of conventional radiography, biomechanical testing and measurements of bone mineral content and density after 2 and 4 months, respectively. Frozen grafts were significantly less integrated after 2 months as compared to fresh grafts. After 4 months, however, the frozen grafts showed an overall reconstruction that was not significantly different from the fresh grafts. Both frozen and fresh grafted segments had only reached 70% strength of intact bone at 4 months. This study indicates that in the long run there are no significant consequences, radiologically or biomechanically, of deep freezing as compared to fresh bone grafts.

References

Oct 1, 1979·Archives of Orthopaedic and Trauma Surgery·H D Sauer, H Schoettle
Nov 1, 2000·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·D G Marchesi
Nov 1, 2000·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·T Floyd, D Ohnmeiss
Mar 14, 2001·The Journal of Bone and Joint Surgery. British Volume·J F Keating, M M McQueen
Nov 22, 2001·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·M Lind, C Bünger
Nov 22, 2001·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·E M ErbeL D Bellincampi
Mar 7, 2006·Techniques in Hand & Upper Extremity Surgery·Jeffrey J PokornyMoheb S Moneim

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