Impact of functional tricuspid regurgitation on heart failure and death in patients with functional mitral regurgitation and left ventricular dysfunction

European Journal of Heart Failure
Eustachio AgricolaAlberto Margonato

Abstract

The prognostic role of tricuspid regurgitation (TR) associated with organic left-sided valvular heart disease is well known. However, no data are available regarding the prognostic value of functional TR (FTR) in patients with functional mitral regurgitation (FMR) and left ventricular (LV) dysfunction. The purpose of this study was to evaluate the prognostic role of FTR for occurrence of heart failure (HF) and mortality in patients with FMR. We enrolled 373 consecutive patients (mean age 68±11 years) with LV dysfunction and at least mild FMR and with or without FTR, both quantitated by echocardiography. The median follow-up was 32 months (range 1-120 months); 132 (35.4%) and 97 patients developed HF or died, respectively. The incidence of HF at 3 and 6 years was 36±2% and 55±4%, respectively. Moderate to severe FTR [hazard ratio (HR) 1.4, 95% confidence interval (CI) 1.1-2.1, P = 0.01) was an independent determinant of HF. The incidence of HF was 41±5, 46±7, 57±7, and 65±8% for patients without, and with mild, moderate, and severe FTR respectively (P = 0.03). At 3 and 6 years the survival free of all-cause mortality was 77.5±2% and 60±3%, respectively. Moderate to severe FTR (HR 1.6, 95% CI 1.2-2.1, P = 0.01) was an independent...Continue Reading

References

Mar 1, 1997·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·A SagieR A Levine
Aug 9, 2001·European Heart Journal·W J RemmeUNKNOWN Task Force for the Diagnosis and Treatment of Chronic Heart Failure, European Society of Cardiology
Mar 6, 2004·The Journal of Thoracic and Cardiovascular Surgery·Patrick M McCarthyEugene H Blackstone
Mar 12, 2004·Journal of the American College of Cardiology·Jayant NathPaul A Heidenreich
Jul 30, 2004·The Journal of Thoracic and Cardiovascular Surgery·Marc RuelThierry G Mesana
Dec 29, 2004·The Annals of Thoracic Surgery·Gilles D DreyfusToufan Bahrami
Jan 18, 2005·Journal of the American College of Cardiology·Francesco GrigioniMaurice Enriquez-Sarano
Jul 11, 2006·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Shih-Hung HsiaoChun-Peng Liu
Feb 15, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Michele De BonisOttavio Alfieri
Jan 31, 2009·Journal of the American College of Cardiology·Avinoam Shiran, Alex Sagie
Apr 29, 2009·European Journal of Heart Failure·Eustachio AgricolaAlberto Margonato
May 4, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Patrizio LancellottiUNKNOWN European Association of Echocardiography
Aug 6, 2010·European Journal of Heart Failure·Kevin DammanUNKNOWN CIBIS-2 Investigators and Committees
Nov 26, 2010·International Journal of Cardiology·Eustachio AgricolaAlberto Margonato
Nov 26, 2010·European Journal of Heart Failure·Heiko UthoffChristian Mueller

❮ Previous
Next ❯

Citations

Jan 24, 2016·European Heart Journal·Maurizio TaramassoFrancesco Maisano
Dec 20, 2014·Journal of the American College of Cardiology·Andreas A KammerlanderJulia Mascherbauer
Mar 14, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Akihiro HirashikiToyoaki Murohara
Feb 24, 2015·JACC. Cardiovascular Interventions·Toby RogersRobert J Lederman
Sep 19, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Maurizio TaramassoFrancesco Maisano
Nov 4, 2016·European Heart Journal·Philippe J van RosendaelJeroen J Bax
Aug 11, 2015·Journal of Cardiovascular Medicine·Eustachio AgricolaAlberto Margonato
Apr 13, 2018·Minerva cardioangiologica·Francesco AnconaEustachio Agricola
Nov 30, 2018·Minerva cardioangiologica·Mizuki MiuraMaurizio Taramasso
Jan 18, 2018·Journal of Cardiovascular Medicine·Michele Di MauroSilvio Romano
Apr 15, 2018·Heart Failure Reviews·Marijana Tadic, Cesare Cuspidi
Sep 25, 2017·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Maurizio Taramasso, Francesco Maisano
Jul 30, 2019·European Journal of Clinical Investigation·Henrike ArfstenGeorg Goliasch
Nov 18, 2019·The Journal of Thoracic and Cardiovascular Surgery·Marcin MalinowskiTomasz A Timek
Feb 25, 2021·European Heart Journal Cardiovascular Imaging·Francesco AnconaEustachio Agricola
Jul 16, 2021·Frontiers in Cardiovascular Medicine·Davide MargonatoEustachio Agricola
Jul 23, 2021·European Journal of Clinical Investigation·Alberto PredaEustachio Agricola

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Nawwar Al-Attar, Ulrik Hvass
Seminars in Thoracic and Cardiovascular Surgery
Judy Hung
© 2021 Meta ULC. All rights reserved