PMID: 16614536Apr 15, 2006Paper

Impact of gastric emptying on levodopa pharmacokinetics in Parkinson disease patients

Clinical Neuropharmacology
Thomas MüllerOliver Goetze

Abstract

Adjunction of the catechol-O-methyltransferase (COMT) inhibitor entacapone (EN) to levodopa/carbidopa (LD/CD) improves motor symptoms in patients with Parkinson disease (PD) by a prolonged elimination of LD. But it is not known whether EN addition influences gastric emptying and thus LD pharmacokinetics and pharmacodynamics. Objectives were to simultaneously determine plasma LD elimination, gastric emptying, and clinical response after a single intake of the same LD dosage as LD/CD--or as (LD/CD/EN) formulation on 2 consecutive days. In both groups, PD patients with delayed gastric emptying had significant lower LD plasma concentrations. Addition of EN did not influence gastric emptying but significantly improved motor response, which was not different for patients with delayed gastric emptying. However, with and without EN adjunction gastric emptying distinctly contributes to the variability of plasma LD bioavailability. This may impact LD delivery to the brain and thus motor response in PD patients. Therefore, fine tuning of LD application, which considers gastric emptying, becomes more and more essential in advanced PD stages with a reduced striatal neuronal dopamine capacity, which is responsible for maintenance of motor re...Continue Reading

References

Jan 1, 1990·British Journal of Clinical Pharmacology·D R RobertsonC F George
Jan 1, 1988·Life Sciences·E NissinenS Kaakkola
May 1, 1971·European Journal of Clinical Investigation·L Rivera-CalimlimJ R Bianchine
Apr 1, 1997·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·P BenetelloM Baraldo
May 16, 2000·Journal of Neural Transmission·T MüllerH Przuntek
Dec 19, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·R HardoffN Giladi
Apr 12, 2003·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M van de CasteeleF Nevens
Jul 10, 2003·Lancet Neurology·Ronald F Pfeiffer
Dec 17, 2004·Clinical Neuropharmacology·Dag Nyholm, Sten-Magnus Aquilonius

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Citations

Sep 11, 2007·Experimental Brain Research·Steven T MooreWilliam G Ondo
Sep 7, 2013·International Journal of Pharmaceutics·Kyung Eun LeeHye Sun Gwak
Dec 24, 2009·Cardiovascular Psychiatry and Neurology·Thomas Müller
Dec 2, 2011·PLoS Currents·Carsten SaftOliver Goetze
Jun 16, 2011·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·D Salat-FoixO Suchowersky
Dec 24, 2013·European Journal of Drug Metabolism and Pharmacokinetics·Yeon Hong LeeHye Sun Gwak
May 29, 2008·Expert Review of Neurotherapeutics·Thomas Müller
Aug 24, 2006·Expert Opinion on Pharmacotherapy·Thomas Müller, Hermann Russ
Jan 21, 2014·Expert Opinion on Drug Metabolism & Toxicology·Livia Dézsi, László Vécsei
Feb 6, 2008·Expert Opinion on Drug Metabolism & Toxicology·Dag Nyholm, Hans Lennernäs
Apr 14, 2010·Expert Opinion on Drug Metabolism & Toxicology·Nelida FernandezMatilde Sierra
Jun 25, 2010·Expert Opinion on Drug Metabolism & Toxicology·Thomas Müller
Nov 18, 2015·Journal of Neural Transmission·Thomas MüllerManfred Gerlach
Sep 11, 2010·Parkinsonism & Related Disorders·Ronald F Pfeiffer
Oct 7, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Tae Kyung KimHye Sun Gwak
May 20, 2009·Parkinsonism & Related Disorders·Anna Krygowska-WajsAnna Sowa-Staszczak
May 9, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Thomas Müller, Wilfried Kuhn
Aug 20, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Michela BarichellaGianni Pezzoli
Apr 30, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Maria G Cersosimo, Eduardo E Benarroch
Feb 27, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Thomas Müller, Wilfried Kuhn
Jun 12, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Thomas MüllerChristoph Erdmann
Nov 27, 2010·Acta Neurologica Scandinavica·T ArcherB Johansson
Mar 27, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L WangY Taché
Oct 24, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Sarah MarrinanDavid J Burn
Sep 22, 2010·Parkinsonism & Related Disorders·Masahiro NagaiMasahiro Nomoto
Dec 3, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Pankaj Jay Pasricha
Sep 26, 2015·Journal of Parkinson's Disease·Lisa Klingelhoefer, Heinz Reichmann
Jan 3, 2012·Parkinsonism & Related Disorders·Zaid S Heetun, Eamonn M M Quigley
Nov 4, 2016·Pharmaceutical Development and Technology·Rana ObaidatTamara Athamneh
Dec 13, 2016·Clinical Nuclear Medicine·Alberto BestettiFrancesca Mancini
May 6, 2011·Clinical Neuropharmacology·Thomas MüllerSiegfried Muhlack
Nov 28, 2018·Expert Opinion on Drug Metabolism & Toxicology·Fabrizio StocchiMargherita Torti
Jan 18, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Siegfried MuhlackThomas Müller

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