Impact of Gd3+ on DNP of [1-13C]pyruvate doped with trityl OX063, BDPA, or 4-oxo-TEMPO.

The Journal of Physical Chemistry. a
Lloyd L LumataZoltan Kovacs

Abstract

Hyperpolarized [1-(13)C]pyruvate has become an important diagnostic tracer of normal and aberrant cellular metabolism for in vitro and in vivo NMR spectroscopy (MRS) and imaging (MRI). In pursuit of achieving high NMR signal enhancements in dynamic nuclear polarization (DNP) experiments, we have performed an extensive investigation of the influence of Gd(3+) doping, a parameter previously reported to improve hyperpolarized NMR signals, on the DNP of this compound. [1-(13)C]Pyruvate samples were doped with varying amounts of Gd(3+) and fixed optimal concentrations of free radical polarizing agents commonly used in fast dissolution DNP: trityl OX063 (15 mM), 4-oxo-TEMPO (40 mM), and BDPA (40 mM). In general, we have observed three regions of interest, namely, (i) a monotonic increase in DNP-enhanced nuclear polarization P(dnp) upon increasing the Gd(3+) concentration until a certain threshold concentration c(1) (1-2 mM) is reached, (ii) a region of roughly constant maximum P(dnp) from c(1) until a concentration threshold c(2) (4-5 mM), and (iii) a monotonic decrease in P(dnp) at Gd(3+) concentration c > c(2). Of the three free radical polarizing agents used, trityl OX063 gave the best response to Gd(3+) doping, with a 300% increa...Continue Reading

References

Aug 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jan H Ardenkjaer-LarsenKlaes Golman
Oct 12, 2007·Journal of the American Chemical Society·Matthew E MerrittA Dean Sherry
Dec 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Matthew E MerrittCraig R Malloy
Jan 19, 2008·Nature Reviews. Cancer·Kevin Brindle
Jul 8, 2008·The Journal of Chemical Physics·S JanninJ J van der Klink
Oct 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Matthew E MerrittCraig R Malloy
Jan 24, 2009·Journal of Magnetic Resonance·Haukur JóhannessonJan Henrik Ardenkjaer-Larsen
Mar 31, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marie A SchroederDamian J Tyler
Apr 9, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ruud B van HeeswijkRolf Gruetter
Aug 22, 2009·Magnetic Resonance Imaging·Janine M LupoSarah J Nelson
Aug 29, 2009·Chemistry : a European Journal·Pernille R JensenMathilde H Lerche
Oct 29, 2009·The Journal of Biological Chemistry·Pernille R JensenMathilde H Lerche
Nov 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ferdia A GallagherKevin M Brindle
Dec 5, 2009·International Journal of Cancer. Journal International Du Cancer·Magnus KarlssonMathilde H Lerche
Dec 22, 2009·Journal of Magnetic Resonance·Mathilde H LercheJan H Ardenkjaer-Larsen
Jan 28, 2010·Journal of the American Chemical Society·Ashish K JindalZoltán Kovács
May 13, 2010·Physical Chemistry Chemical Physics : PCCP·Cristina CudalbuRolf Gruetter
May 19, 2010·Journal of Magnetic Resonance·David M WilsonJohn Kurhanewicz
Jun 25, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Angus Z LauCharles H Cunningham
Jul 1, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ralph E HurdDirk Mayer
Dec 17, 2010·Molecular Cancer Therapeutics·Sarah E BohndiekKevin M Brindle
Jan 26, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sam E DayKevin M Brindle
Feb 3, 2011·Physics in Medicine and Biology·Lloyd LumataMatthew Merritt
Mar 16, 2011·Neoplasia : an International Journal for Oncology Research·John KurhanewiczCraig R Malloy
Mar 25, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Aaron K GrantDavid C Alsop
Mar 31, 2011·Journal of the American Chemical Society·Björn CorziliusRobert G Griffin
May 5, 2011·Journal of the American Chemical Society·Lloyd LumataZoltan Kovacs
Jun 11, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kevin M BrindleMikko I Kettunen
Jun 23, 2011·Journal of the American Chemical Society·Sarah E BohndiekKevin M Brindle
Jun 23, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ferdia A GallagherKevin M Brindle
Sep 16, 2011·Chemistry : a European Journal·Lloyd LumataZoltan Kovacs
Oct 15, 2011·Angewandte Chemie·Lloyd LumataZoltan Kovacs
Nov 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Matthew E MerrittShawn C Burgess

❮ Previous
Next ❯

Citations

Feb 28, 2016·Journal of Magnetic Resonance·Fabian JähnigMatthias Ernst
Dec 19, 2012·Journal of Magnetic Resonance·Lloyd L LumataZoltan Kovacs
Dec 1, 2015·Physical Chemistry Chemical Physics : PCCP·Frédéric A PerrasMarek Pruski
Nov 5, 2014·Biochemistry·Arnaud Comment, Matthew E Merritt
Sep 26, 2015·Physical Chemistry Chemical Physics : PCCP·Enrico RaveraGiacomo Parigi
Apr 6, 2016·Physical Chemistry Chemical Physics : PCCP·I KaminkerS Vega
Apr 10, 2016·Magnetic Resonance in Chemistry : MRC·Jian-Xiong WangCraig R Malloy
Jun 22, 2015·The Journal of Chemical Physics·Deni ManceKonstantin L Ivanov
Apr 20, 2016·Physical Chemistry Chemical Physics : PCCP·Hikari A I YoshiharaArnaud Comment
Feb 18, 2014·Journal of Magnetic Resonance·Sean Bowen, Jan Henrik Ardenkjaer-Larsen
Nov 26, 2013·Physical Chemistry Chemical Physics : PCCP·Sonia Colombo SerraFabio Tedoldi
Dec 24, 2013·Chemical Society Reviews·Kayvan R Keshari, David M Wilson
Jan 15, 2015·Organic & Biomolecular Chemistry·J L Muñoz-GómezJ Vidal-Gancedo
Jul 19, 2016·Physical Chemistry Chemical Physics : PCCP·Andhika KiswandhiLloyd Lumata
Jul 6, 2016·Magnetic Resonance in Chemistry : MRC·Peter NiedbalskiLloyd Lumata
Sep 27, 2016·Analytical Biochemistry·Mor Mishkovsky, Arnaud Comment
Jul 14, 2017·Physical Chemistry Chemical Physics : PCCP·Fabian JähnigMatthias Ernst
Jun 9, 2017·Magnetic Resonance in Chemistry : MRC·Andhika KiswandhiLloyd Lumata
Dec 6, 2018·Angewandte Chemie·Andrea CapozziJan Henrik Ardenkjaer-Larsen
Aug 16, 2019·Physical Chemistry Chemical Physics : PCCP·Ram B KhattriMatthew E Merritt
Jan 11, 2020·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Talia HarrisRachel Katz-Brull
Sep 10, 2017·The Journal of Biological Chemistry·You ZhuoJames H Prestegard
Apr 17, 2013·Physical Chemistry Chemical Physics : PCCP·David T PeatJohn R Owers-Bradley
Sep 5, 2015·Physical Review Letters·Andrea De Luca, Alberto Rosso
Dec 16, 2017·Physical Chemistry Chemical Physics : PCCP·Ali A SirusiMatthew E Merritt
Apr 5, 2013·Physical Chemistry Chemical Physics : PCCP·Lloyd LumataZoltan Kovacs
Jun 27, 2014·Physical Chemistry Chemical Physics : PCCP·Ting Ann SiawSong-I Han
Jan 9, 2017·The Journal of Chemical Physics·Peter NiedbalskiLloyd Lumata
Apr 14, 2017·Magnetic Resonance in Chemistry : MRC·Andhika KiswandhiLloyd Lumata
Sep 4, 2014·Physical Chemistry Chemical Physics : PCCP·Michael BatelMatthias Ernst
Dec 4, 2012·RSC Advances·Lloyd LumataZoltan Kovacs
May 17, 2013·Physical Chemistry Chemical Physics : PCCP·Lloyd LumataMatthew E Merritt
Apr 7, 2017·Physics in Medicine and Biology·Erin B AdamsonSean B Fain
Aug 10, 2018·The Journal of Chemical Physics·Christopher ParishLloyd Lumata
Jan 7, 2020·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Neil J Stewart, Shingo Matsumoto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Physical Chemistry Chemical Physics : PCCP
Lloyd L LumataMatthew E Merritt
The Journal of Chemical Physics
Sami JanninJ J van der Klink
Journal of the American Chemical Society
Christian LudwigUlrich L Günther
© 2021 Meta ULC. All rights reserved