Impact of Gender and Age on the Prognosis of Differentiated Thyroid Carcinoma: a Retrospective Analysis Based on SEER

Hormones & Cancer
Dan ZhangGaosong Wu

Abstract

The incidence of thyroid cancer in females is significantly higher than that in males; however, females are more likely to have more favorable outcomes. We aimed to determine the characteristics of differentiated thyroid carcinoma (DTC) subtypes in males and females, and to compare their clinical behavior and survival. A total of 68,337 cases were recruited from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program. The disease-specific survival (DSS) of follicular variant papillary thyroid carcinoma (FVPTC) and follicular thyroid carcinoma (FTC) were similar to that of classical variant papillary thyroid carcinoma (CPTC) in male patients (FVPTC vs. CPTC, adjusted hazard ratio (aHR) = 0.947, P = 0.776; FTC vs. CPTC, aHR = 1.512, P = 0.104). In premenopausal female (< 55 years old), FVPTC had better DSS than CPTC (aHR = 0.321, P = 0.038) while FTC had worse DSS than CPTC (aHR = 3.272, P = 0.013); in postmenopausal female, FTC had poorer prognosis than CPTC (aHR = 2.145, P = 0.002), no statistical difference was found between CPTC and FVPTC (aHR = 0.724, P = 0.087). For patients younger than 55 years, women had significantly better DSS compared with men with CPTC (aHR = 0.376, P < 0.001) and F...Continue Reading

References

Aug 1, 1979·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D P ByarM van Glabbeke
Oct 1, 1990·American Journal of Surgery·M P CunninghamA Fremgen
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·V A LiVolsi, S L Asa
Nov 1, 1994·The American Journal of Medicine·E L Mazzaferri, S M Jhiang
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Catharina Ihre LundgrenPaul W Dickman
Jul 15, 2003·Endocrine Pathology·Qi-Hui ZhaiRicardo V Lloyd
Oct 17, 2003·American Journal of Epidemiology·M WeinsteinS Pincus
Sep 21, 2006·Clinical Endocrinology·Andreas MachensHenning Dralle
Nov 30, 2007·Endocrine-related Cancer·Garcilaso Riesco-Eizaguirre, Pilar Santisteban
Aug 16, 2008·Endocrine Journal·Yasuhiro Ito, Akira Miyauchi
Sep 24, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R SciutoC L Maini
Dec 15, 2010·Future Oncology·Reza RahbariElectron Kebebew
Jan 10, 2012·Thyroid : Official Journal of the American Thyroid Association·Sara J SchonfeldAlina V Brenner
Jan 31, 2012·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shilpi RajoriaRaj K Tiwari
Apr 13, 2012·The Journal of Clinical Endocrinology and Metabolism·J JonklaasUNKNOWN National Thyroid Cancer Treatment Cooperative Study Group
Jan 31, 2013·Thyroid : Official Journal of the American Thyroid Association·Briseis Aschebrook-KilfoySusan S Devesa
Mar 13, 2013·Thyroid : Official Journal of the American Thyroid Association·Xiao-Min YuRebecca S Sippel
Apr 8, 2014·The Journal of Clinical Endocrinology and Metabolism·Kenneth D Burman
Apr 1, 2017·JAMA : the Journal of the American Medical Association·Hyeyeun LimCari M Kitahara
Mar 1, 2011·Expert Review of Endocrinology & Metabolism·Reina YaoSam M Wiseman

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Citations

Dec 11, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Seong Young KwonUNKNOWN Korean Society of Nuclear Medicine (KSNM) Thyroid Cancer Clinical Trial Network (CTN) Retrospective Cohort Study Group
Nov 14, 2018·International Journal of Endocrinology·R LaurettaM Appetecchia
Jan 21, 2021·Cancer Management and Research·Menghui LiJuntian Liu
Feb 29, 2020·Visceral Medicine·Kerstin LorenzMalik Elwerr
Jan 1, 2022·Thyroid : Official Journal of the American Thyroid Association·Leila ShobabLeonard Wartofsky

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