Impact of gender on the metabolism of apolipoprotein A-I in HDL subclasses LpAI and LpAI:AII in older subjects

Arteriosclerosis, Thrombosis, and Vascular Biology
M Tilly-KiesiE J Schaefer

Abstract

The behavior of apolipoprotein (apo) A-I in lipoprotein (Lp) AI and LpAI:AII was studied in 11 postmenopausal females and 11 males matched for plasma triglyceride and total cholesterol levels. Subjects consumed a baseline diet [35% fat (14% saturated, 15% monounsaturated, and 7% polyunsaturated), 15% protein, 49% carbohydrate, and 147 mg cholesterol/1000 kcal] for 6 weeks before the start of the kinetic study. At the end of the diet period, using a primed-constant infusion of [5,5,5-2H3]leucine, residence times (RT) and secretion rates (SR) of apoA-I were determined in 2 subpopulations of high-density lipoprotein (HDL) particles, LpAI and LpAI:AII. Plasma total cholesterol, low-density lipoprotein cholesterol, and triglyceride concentrations were similar in males and females. The mean plasma HDL cholesterol concentration in males (1.14 +/- 0.23 mmol/L; mean +/- SD) was lower than in females (1.42 +/- 0.18 mmol/L; P =. 0034). Similarly, the mean plasma concentration of apoA-I in males (130 +/- 21 mg/dL) was lower than that in females (150 +/- 19 mg/dL; P = .0421). The RT of apoA-I in either LpAI or LpAI:AII was similar between men and women. Despite the higher plasma apo A-I levels in female compared with male subjects, total ap...Continue Reading

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Citations

Jun 1, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lianqun JiaShiyin Long
Mar 27, 2004·Metabolism: Clinical and Experimental·Marju Tilly-KiesiAlice H Lichtenstein
Sep 10, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·F MagkosB Mittendorfer
Sep 11, 1999·Current Opinion in Lipidology·P L Colvin, J S Parks
Jul 6, 2000·Current Opinion in Lipidology·J B MarshE J Schaefer
Jun 5, 2003·Journal of Lipid Research·Marian C CheungJohn D Brunzell
Nov 22, 2007·The Journal of Clinical Endocrinology and Metabolism·Esther M M OoiP Hugh R Barrett
Jul 13, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Lúcia C N ErberichMarileia Scartezini
Sep 7, 2002·Antioxidants & Redox Signaling·Andras PerlKatalin Banki
Dec 29, 2004·Free Radical Research·Anna KrzepiłkoTomasz Biliński
Jul 14, 2001·The American Journal of Clinical Nutrition·L C LyuE J Schaefer
Jun 15, 2012·Atherosclerosis·Patricia BlackburnJean-Pierre Després
May 29, 2008·Journal of Proteome Research·Adamo ValleFernando Goglia
Jun 16, 2007·Metabolism: Clinical and Experimental·Francine K WeltyJulian B Marsh

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