Impact of Genetic Polymorphism in the β2-Receptor Gene on Risk of Severe Hypoglycemia in Patients With Type 1 Diabetes

The Journal of Clinical Endocrinology and Metabolism
Kim Zillo RokampUlrik Pedersen-Bjergaard

Abstract

Severe hypoglycemic events are unevenly distributed in people with type 1 diabetes, making a genetic influence probable. Of the common adrenoceptor β-2 receptor gene (ADRB2) polymorphisms, the Arg16 allele is associated with receptor downregulation and reduced agonist-mediated endogenous glucose production. We tested the hypothesis that the Arg16 variant is associated with severe hypoglycemia. A cohort of 311 patients with type 1 diabetes reported severe hypoglycemic events retrospectively in a validated questionnaire. The patients were characterized by diabetes history, state of hypoglycemia awareness, C-peptide status, HbA1c, and ADRB2 genotype. The ADRB2 Gly16Arg genotype distribution was in Hardy-Weinberg equilibrium. The rate of severe hypoglycemia differed among all genotypes (P = 0.01). Patients homozygous for the Arg16 genotype (AA; n = 60) had a relative rate (RR) of severe hypoglycemia of 2.2 (95% CI, 1.3 to 3.6) compared with patients homozygous for the Gly16 genotype (GG; n = 116; P = 0.002). Among patients with impaired awareness or unawareness (n = 175), those with the AA genotype (n = 33) had an RR of severe hypoglycemia of 3.2 (95% CI, 1.7 to 6.0) compared with patients with the GG genotype (n = 58; P < 0.000). ...Continue Reading

References

Jun 6, 2003·Diabetes/metabolism Research and Reviews·Ulrik Pedersen-BjergaardBirger Thorsteinsson
Dec 3, 2003·Naunyn-Schmiedeberg's Archives of Pharmacology·K LeineweberO-E Brodde
Apr 10, 2004·Life Sciences·Kirsten Leineweber, Otto-Erich Brodde
Sep 24, 2004·Diabetes/metabolism Research and Reviews·Ulrik Pedersen-BjergaardBirger Thorsteinsson
Dec 3, 2005·American Journal of Respiratory and Critical Care Medicine·Michael E WechslerUNKNOWN National Heart, Lung, and Blood Institute's Asthma Clinical Research Network
May 18, 2006·The Journal of Clinical Endocrinology and Metabolism·Bastiaan E De GalanPaul Smits
Nov 27, 2008·Diabetes·Philip E Cryer
Oct 3, 2009·Journal of Diabetes and Its Complications·Thomas Høi-HansenBirger Thorsteinsson
Sep 10, 2011·Pediatric Pulmonology·Christopher L CarrollCraig M Schramm
Jan 18, 2016·The Journal of Allergy and Clinical Immunology·Steve TurnerUNKNOWN Pharmacogenomics in Childhood Asthma Consortium
Jul 12, 2017·Pharmacogenetics and Genomics·Bas J SchouwenbergBastiaan E de Galan

❮ Previous
Next ❯

Citations

Oct 26, 2018·The Journal of Clinical Endocrinology and Metabolism·Fady Hannah-Shmouni, Roberto Londo-Mendoza

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.