Impact of genetic polymorphisms near the IL28B gene and amino acid substitutions in the hepatitis C virus core region on interferon sensitivity/resistance in patients with chronic hepatitis C

Journal of Medical Virology
Hidenori ToyodaFumihiko Matsuda

Abstract

It has been reported that genetic polymorphisms near the IL28B gene or amino acid substitutions in hepatitis C virus (HCV) core protein are associated with the clinical outcome of peginterferon (PEG-IFN) and ribavirin combination therapy. The impact of these factors on the pure sensitivity/resistance to interferon was evaluated. Changes in the HCV RNA levels 24, 48, 72, and 120 hr after administering a single dose of standard interferon (IFN) were measured in 156 HCV-infected patients. The changes were compared based on the genetic polymorphisms near the IL28B gene or amino acid substitutions in the HCV core region. Among patients with HCV genotype 1b, there were differences in the reduction and subsequent increase in HCV RNA levels after administering IFN based on rs8099917 genetic polymorphisms. Amino acid substitutions at residue 70 were associated with differences in the changes in HCV RNA levels only in patients with TG/GG genotype. Multivariate analyses showed that genetic polymorphisms near the IL28B gene was the sole independent factor that was associated with the reduction in HCV RNA levels after administering IFN and the final response to the combination therapy. Among patients infected with HCV genotype 2a or 2b, the...Continue Reading

References

Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C NiederauD Häussinger
Mar 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN American Association for the Study of Liver Diseases
Sep 15, 2009·Nature Genetics·Vijayaprakash SuppiahJacob George

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Citations

Oct 12, 2013·Pharmacotherapy·Marina Kawaguchi-Suzuki, Reginald F Frye
Jan 28, 2014·Clinical Biochemistry·Mark A CervinskiGregory J Tsongalis
Apr 14, 2012·Current Opinion in Organ Transplantation·Lydia M Petrovic

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