PMID: 11340572May 8, 2001Paper

Impact of genetic polymorphisms of 17-hydroxylase cytochrome P-450 (CYP17) and steroid 5alpha-reductase type II (SRD5A2) genes on prostate-cancer risk among the Japanese population

International Journal of Cancer. Journal International Du Cancer
Y YamadaT Shiraishi

Abstract

Steroid hormones, especially testosterone, play important roles in the carcinogenesis of prostate cancer, and several studies have reported changes in risk with polymorphisms of genes involved in steroid metabolism. One example is the CYP17 gene, which has a polymorphic T-to-C substitution in the 5'-untranslated region giving rise to A1 (T) and A2 (C) alleles. Steroid 5alpha-reductase type II (SRD5A2), which converts testosterone to the metabolically more active dihydrotestosterone, exhibits 2 polymorphisms: V89L, which substitutes leucine for valine at codon 89, and A49T, which substitutes threonine for alanine at codon 49. We therefore designed a case-control study of 105 prostate-cancer patients and 210 controls with benign prostatic hyperplasia for the purpose of investigating the association between prostate-cancer risk and polymorphisms in the SRD5A2 and CYP17 genes among the Japanese. The frequency of the CYP17 A2/A2 genotype in cases (18.8%) was higher than in controls (14.5%). Compared with the A1/A1 genotype, the odds ratio for the A2/A2 genotype was 2.39 (95% confidence interval 1.04-5.46, p = 0.04). The frequency of the SRD5A2 LL genotype in cases (29.3%) was also slightly higher than in controls (24.6%), but this w...Continue Reading

References

Jan 1, 1992·Hormone Research·M R Waterman, D S Keeney
May 1, 1991·Japanese Journal of Cancer Research : Gann·H ShimizuL Bernstein
Aug 21, 1996·Journal of the National Cancer Institute·P H GannM J Stampfer
Jun 1, 1997·Clinical Genetics·F VilchisB Chávez
Dec 11, 1999·Pharmacogenetics·M WadeliusE Rane
Jul 18, 2000·International Journal of Cancer. Journal International Du Cancer·A GsurM Micksche

❮ Previous
Next ❯

Citations

Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·B ChangJ Xu
Jul 12, 2002·The Prostate·Ann W HsingFrank Z Stanczyk
May 5, 2005·Current Urology Reports·Javier HernandezIan M Thompson
Jan 5, 2011·Cancer Epidemiology·Yousra SouidenKacem Mahdouani
Mar 26, 2002·Cancer Letters·Lev M BersteinIrina G Kovalenko
Sep 13, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shaw WatanabeYuriko Kikuchi
Aug 7, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Domingo NavarroBonifacio N Díaz-Chico
May 13, 2008·Human Molecular Genetics·C Leigh PearceBrian E Henderson
Apr 23, 2004·Pharmacogenomics·Giuseppe NovelliJuergen K V Reichardt
Dec 19, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jonathan BeesleyUNKNOWN Australian Breast Cancer Family Study
Jan 25, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Elizabeth A Platz, Edward Giovannucci
Apr 6, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Hong Gee Sim, Christopher W S Cheng
Jan 28, 2005·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Y S PuJ Chen
Apr 11, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Taro TsujinoTakeshi Maruo
Apr 25, 2003·International Journal of Cancer. Journal International Du Cancer·Najib LamharziChu Chen
Sep 2, 2003·International Journal of Cancer. Journal International Du Cancer·M Patricia MadiganAnn W Hsing
Oct 21, 2004·Cancer·David G BostwickBarry Timms
Sep 18, 2009·The Prostate·Chunyang WangRuifa Han
May 27, 2010·The Prostate·Jonathan L WrightJanet L Stanford
May 12, 2004·The Pharmacogenomics Journal·M KlotsmanK E Hartmann
May 22, 2002·Endocrinology·Jacques SimardFernand Labrie
Nov 13, 2004·The Prostate·Cinzia AntognelliEttore Mearini
Sep 24, 2020·American Journal of Men's Health·Clement Yaw EffahYongjun Wu
Apr 30, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Arezu Karimpur-ZahmatkeshMohammad Yaghoobi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.