Nov 5, 2018

Impact of genetic variations on the human brain: when and where?

BioRxiv : the Preprint Server for Biology
Kevin VervierJacob Michaelson


Genetic studies have found candidates in most of neurological and psychiatric conditions. However, it remains challenging to assess, in which brain region, and when in the brain development, a mutation is more likely to have an impact, especially for intergenic loci. Here we present, BRAVA, a publicly available resource for estimating genetic mutations spatio-temporal context on the human brain. Different contexts were observed for schizophrenia associated loci, suggesting both neurodevelopmental and late onset components.

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Mentioned in this Paper

Neurodevelopmental Disorders
Psychiatry Specialty
Genetic Studies
Genetic Loci
Mutation Abnormality
Brain Region
Brain Development

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