Impact of germinal center-associated nuclear protein polymorphisms on breast cancer risk and prognosis in a Japanese population

Breast Cancer : the Journal of the Japanese Breast Cancer Society
Haruru KotaniKeitaro Matsuo

Abstract

Germinal center-associated nuclear protein (GANP) is a phosphoprotein involved in mRNA export and regulation of DNA recombination. Although GANP expression in human breast cancer tissue is associated with breast cancer prognosis, the association between the genetic background of GANP and susceptibility and prognosis of breast cancer is unclear. We selected 694 breast cancer cases and 1376 age- and menopausal status-matched non-cancer controls from the Hospitable-based Epidemiologic Research Program, conducted at Aichi Cancer Center between 2001 and 2005. We evaluated the impact of two polymorphisms at the GANP locus (rs2839178 and rs11702450) on the susceptibility and prognosis of breast cancer. Reference alleles were defined as the A allele for rs2839178 and G allele for rs11702450. The GG genotype of rs2839178 was statistically significantly associated with breast cancer risk (odds ratio [OR] 0.48, 95% confidence interval [CI] 0.30-0.76, P = 0.002). In prognostic analysis, compared to those with AA genotype of rs2839178, patients with AG or GG genotypes had longer disease-free survival (DFS) (hazard ratio [HR] 0.71, 95% CI 0.49-1.04 and HR 0.42, 95% CI 013-1.42, respectively, P for trend = 0.04). eQTL analysis indicated that ...Continue Reading

References

Jan 1, 1993·Epidemiologic Reviews·J L KelseyE M John
Aug 1, 2008·Molecular Biology of the Cell·Cristina González-AguileraAndrés Aguilera
Apr 14, 2010·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Nobukazu OkamotoNobuo Sakaguchi
Feb 14, 2016·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Naruto TairaHirofumi Mukai

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Citations

Jun 26, 2021·Nature Communications·Martin KosarMarco Foiani

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