Impact of Ginkgo Biloba Extract EGb 761 on ischemia/reperfusion - induced oxidative stress products formation in rat forebrain.

Cellular and Molecular Neurobiology
A UríkováJan Lehotský

Abstract

Dysbalance in reactive oxygen/nitrogen species is involved in the pathogenesis of cerebral ischemia/reperfusion injury (IRI). Ginkgo biloba extract (Egb 761) pre-treatment was used to observe potential antioxidant/neuroprotective effect after global ischemia/reperfusion. Egb 761 significantly decreased the level of lipoperoxidation (LPO) in rat forebrain total membrane fraction (homogenate) induced by in vitro oxidative stress (Fe(2+)+H(2)O(2)). In animals subjected to four-vessel global ischemia for 15 min and 2-24 h reperfusion the EGb pretreatment slightly decreased LPO in forebrain homogenate. However, as detected in EGb treated group, the LPO-induced lysine conjugates are attenuated in comparison to non-treated IRI animals. EGb significantly improved parameters which indicate forebrain protein oxidative damage after IRI. The intensity of tryptophane fluorescence was increased by the 18.2% comparing to non-treated IRI group and bityrosine fluorescence was significantly decreased in ischemic (21%) and 24 h reperfused (15.9%) group in comparison non-treated IRI group. In addition, the level of total free SH- groups in pre-treated animals was significantly higher comparing to non-treated animals. Our results indicate that extr...Continue Reading

References

Jan 1, 1989·Free Radical Research Communications·B Halliwell
Sep 1, 1983·Stroke; a Journal of Cerebral Circulation·W A PulsinelliT E Duffy
Nov 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·U DirnaglA Villringer
Jan 1, 1994·Methods in Enzymology·L MarcocciM Gardès-Albert
Jan 1, 1994·Methods in Enzymology·C Giulivi, K J Davies
Jan 1, 1994·Methods in Enzymology·M L Hu
Jan 1, 1994·Methods in Enzymology·N DoussetG Curatola
Jan 1, 1994·Methods in Enzymology·D K Das, N Maulik
Apr 1, 1994·Scandinavian Journal of Clinical and Laboratory Investigation·M TausG Curatola
Sep 1, 1996·Molecular and Chemical Neuropathology·M MatejovicováV Mézesová
Dec 31, 1997·Stroke; a Journal of Cerebral Circulation·N J SolenskiK S Lee
Nov 4, 1998·The American Journal of Chinese Medicine·T TadanoK Kisara
Jul 14, 1999·Biochemical Pharmacology·D JanssensC Michiels
Jan 21, 2000·Free Radical Biology & Medicine·M J DaviesR T Dean
Mar 29, 2000·The International Journal of Biochemistry & Cell Biology·P KaplánP Racay
Oct 4, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Takeshi HayashiPak H Chan
Aug 4, 2005·Neurochemical Research·Viera DanielisováJozef Burda

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Citations

Dec 7, 2007·Cellular and Molecular Neurobiology·Monika SivonováJan Lehotský
Feb 25, 2014·Annals of Vascular Surgery·Serdar BademEnver Dayioglu
Mar 13, 2009·High Altitude Medicine & Biology·Martha C Tissot van PatotPeter H Hackett
Mar 15, 2016·Journal of Photochemistry and Photobiology. B, Biology·Amel F M Ismail, Sawsan M El-Sonbaty
Nov 26, 2015·Integrative Medicine Insights·Kevin M Nash, Zahoor A Shah
Jun 2, 2020·Phytotherapy Research : PTR·Muqeet WahidMuhammad Hassham Hassan Bin Asad

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