Impact of GnRH ovarian stimulation protocols on intracytoplasmic sperm injection outcomes.

Reproductive Biology and Endocrinology : RB&E
Fátima PintoA Barros

Abstract

Although a large number of studies have been conducted in relation to ovarian response and pregnancy after GnRH agonist and GnRH antagonist controlled ovarian hyperstimulation protocols, most of them used single or combinations of a few predictive factors, and none included the stimulation protocol in the multivariable analysis. The present study was thus primarily designed to investigate the predictive value of the stimulation protocol and to analyze the possible relationships between stimulation protocols and treatment outcomes after adjusting for a large set of variables that potentially affect reproductive outcomes. Factors related to pregnancy achievement and predictive of the number of oocytes retrieved and high quality of the embryos obtained were also analyzed. To analyze the impact of GnRH ovarian stimulation protocols on the independent predictors of ovarian response, high quality embryos and clinical pregnancy, two groups out of 278 ICSI treatment cycles were compared prospectively, 123 with a GnRH agonist and 155 with a GnRH antagonist, with multivariable analysis assessing outcomes after adjusting for a large set of variables. Antagonists were significantly associated with lower length and total dose of GnRH, lower...Continue Reading

References

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Citations

Jul 15, 2015·Zygote : the Biology of Gametes and Early Embryos·Ana Sílvia Pires-LuísMário Sousa
Jun 24, 2015·Reproductive Biology and Endocrinology : RB&E·Mário SousaAlberto Barros
May 26, 2016·Journal of Assisted Reproduction and Genetics·Mário SousaAlberto Barros
Sep 3, 2013·Zygote : the Biology of Gametes and Early Embryos·M SousaA Barros
May 28, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Tugba KinayAli Haberal
Apr 15, 2020·Zygote : the Biology of Gametes and Early Embryos·Sofia CoelhoMário Sousa
Aug 9, 2020·Journal of Assisted Reproduction and Genetics·Ana Catarina LopesMário Sousa
May 25, 2021·Clinical and Experimental Reproductive Medicine·Abdel Hameed I M EbidMahmoud M A Soliman

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