Impact of graded hypothermia on coagulation and fibrinolysis

The Journal of Surgical Research
Chryssoula StaikouMichael Kontos

Abstract

Hypothermia has a detrimental effect on hemostatic mechanism. The purpose of this experimental study was to investigate the effect of graded hypothermia on markers of the anticoagulant system (antithrombin III and protein C) and fibrinolytic system (plasminogen, α(2)-antiplasmin), and on vascular wall and other tissue specimens. Ten New Zealand rabbits were subjected to mild and then moderate core hypothermia of 32 °C for 60 min. Blood samples were obtained at normothermic (T(1)), mild (T(2)), and moderate (T(3)) hypothermic conditions. Chromogenic assay methods were used to determine quantitatively (%) the activity of antithrombin III, protein C, plasminogen, and α(2)-antiplasmin. Hypothermic values were compared with the normothermic values. Tissue and vessel wall specimens were examined under light microscope. Reduction of activity (%) from normothermia (T(1)) to mild (T(2)) and moderate (T(3)) hypothermia was found for antithrombin III (103.40 ± 12.54, 87.40 ± 13.50, and 82.70 ± 20.78, respectively, with statistically significant difference between T(1)-T(3): P = 0.03), for protein C (70.1 ± 7.51, 56.30 ± 8.34, and 53.1 ± 7.34, with statistically significant difference between T(1)-T(2) and T(1)-T(3): P = 0.015 for both com...Continue Reading

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Citations

Oct 12, 2010·Stroke; a Journal of Cerebral Circulation·Midori A Yenari, Thomas M Hemmen
Apr 3, 2012·Techniques in Vascular and Interventional Radiology·Francesca Tari CaponeFrancesco Orzi
Jan 15, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Roland CouturierStanislas Grassin-Delyle
Dec 3, 2013·Critical Care Nurse·Stavros GourgiotisStylianos Grammenos
Oct 2, 2021·World Journal for Pediatric & Congenital Heart Surgery·Wolfgang BöttcherJoachim Photiadis

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