Impact of growth factors in the regulation of apoptosis in low-risk myelodysplastic syndromes.

Medical Oncology
R Tehranchi

Abstract

Increased apoptosis of hematopoietic progenitors is a hallmark of myelodysplastic syndromes (MDS) and results in ineffective hematopoiesis. Erythroid apoptosis is thought to be the main mechanism underlying the severe anemia observed in the low-risk subgroups, refractory anemia (RA) and RA with ringed sideroblasts (RARS). Treatment with erythropoietin (Epo) alone or in combination with granulocyte colony-stimulating factor (G-CSF) may significantly improve anemia and reduce bone marrow apoptosis. A synergistic effect between Epo and G-CSF has been observed in the clinic, in particular in RARS. However, the molecular mechanisms beyond the anti-apoptotic effect of these growth factors have not been fully understood. This paper outlines the potential mechanisms underlying the augmented apoptosis during the erythroid differentiation in low-risk MDS as well as the anti-apoptotic effect of the growth factors.

Citations

Jan 1, 2009·Current Hematologic Malignancy Reports·Anders OsterborgJeanette Lundin
Mar 28, 2008·Wiener klinische Wochenschrift·Peter Valent, Klaus Lechner
Jun 20, 2007·Leukemia & Lymphoma·Giovanni D'Arena, Nicola Cascavilla
Apr 25, 2007·Leukemia & Lymphoma·Giovanni d'ArenaAntonio Pinto
Jan 16, 2018·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Renee K McAlisterNishitha M Reddy

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