Impact of growth hormone and dehydroepiandrosterone on protein metabolism in glucocorticoid-treated patients

The Journal of Clinical Endocrinology and Metabolism
Morton G BurtKen K Y Ho

Abstract

Chronic pharmacological glucocorticoid (GC) use causes substantial morbidity from protein wasting. GH and androgens are anabolic agents that may potentially reverse GC-induced protein loss. Our objective was to assess the effect of GH and dehydroepiandrosterone (DHEA) on protein metabolism in subjects on long-term GC therapy. This was an open, stepwise GH dose-finding study (study 1), followed by a randomized cross-over intervention study (study 2). The studies were performed at a clinical research facility. In study 1, six subjects (age 69+/-4 yr) treated with long-term (>6 months) GCs (prednisone dose 8.3+/-0.8 mg/d) were studied before and after two sequential GH doses (0.8 and 1.6 mg/d) for 2 wk each. In study 2, 10 women (age 71+/-3 yr) treated with long-term GCs (prednisone dose 5.4+/-0.5 mg/d) were studied at baseline and after 2-wk treatment with GH 0.8 mg/d, DHEA 50 mg/d, or GH and DHEA (combination treatment). Changes in whole body protein metabolism were assessed using a 3-h primed constant infusion of 1-[13C]leucine, from which rates of leucine appearance, leucine oxidation, and leucine incorporation into protein were estimated. In study 1, GH 0.8 and 1.6 mg/d significantly reduced leucine oxidation by 19% (P=0.03) ...Continue Reading

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Citations

Oct 2, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gregory C HendersonK Sreekumaran Nair
Feb 6, 2013·Nature Reviews. Endocrinology·Gherardo Mazziotti, Andrea Giustina
Sep 18, 2008·Arquivos brasileiros de endocrinologia e metabologia·Carlos Eduardo Martinelli, Heloísa M Cunha Palhares

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