Impact of Growth Restriction and Other Prenatal Risk Factors on Cord Blood Iron Status in Prematurity

Journal of Pediatric Hematology/oncology
Patrick J McCarthyPamela J Kling

Abstract

To determine whether prenatal risk factors (RFs) that predict cord blood iron status in term newborns also predict iron status of premature newborns. Cord blood iron indices from 80 preterm newborns were compared with historical and demographic RFs for developing iron deficiency if born at term. The presence of multiple RFs did not incrementally interfere with cord iron status in preterm newborns. Poorer iron status accompanied being small for gestational age in prematurity, but other RFs, including diabetes, had relatively little impact. Growth-restricted preterm newborns are at risk for poor iron endowment, likely due to uteroplacental insufficiency. Other RFs were less impactful on iron status of premature newborns than in term newborns, likely reflecting that disruptive effects of RFs are more impactful in the third trimester. Understanding RFs for poor iron endowment is important for clinical recognition and treatment of premature babies.

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Citations

Dec 16, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·B C MacQueenJ Kaplan
May 12, 2017·Global Pediatric Health·Brianna C MacQueenRobert D Christensen
Jul 28, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Erick GerdayRobert D Christensen
Aug 19, 2020·Journal of Pediatric Gastroenterology and Nutrition·Berthold KoletzkoMartin W Weber
Oct 24, 2020·Journal of Pediatric Gastroenterology and Nutrition·Berthold KoletzkoMartin W Weber

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Methods Mentioned

BETA
SGA

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