Impact of Haemodialysis on Insulin Kinetics of Acute Kidney Injury Patients in Critical Care

Journal of medical and biological engineering
Ummu K JamaludinGeoffrey M Shaw

Abstract

Critically ill patients are occasionally associated with an abrupt decline in renal function secondary to their primary diagnosis. The effect and impact of haemodialysis (HD) on insulin kinetics and endogenous insulin secretion in critically ill patients remains unclear. This study investigates the insulin kinetics of patients with severe acute kidney injury (AKI) who required HD treatment and glycaemic control (GC). Evidence shows that tight GC benefits the onset and progression of renal involvement in precocious phases of diabetic nephropathy for type 2 diabetes. The main objective of GC is to reduce hyperglycaemia while determining insulin sensitivity. Insulin sensitivity (S I ) is defined as the body response to the effects of insulin by lowering blood glucose levels. Particularly, this study used S I to track changes in insulin levels during HD therapy. Model-based insulin sensitivity profiles were identified for 51 critically ill patients with severe AKI on specialized relative insulin nutrition titration GC during intervals on HD (OFF/ON) and after HD (ON/OFF). The metabolic effects of HD were observed through changes in S I over the ON/OFF and OFF/ON transitions. Changes in model-based S I at the OFF/ON and ON/OFF trans...Continue Reading

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Citations

Aug 16, 2015·Asian Pacific Journal of Tropical Medicine·Na-Na BaoLi-Rong Hao
Jun 25, 2017·Critical Care : the Official Journal of the Critical Care Forum·Vincent UyttendaeleJ Geoffrey Chase
Jun 2, 2020·Journal of Diabetes Science and Technology·Jennifer J OrmsbeeJ Geoffrey Chase
Jan 23, 2021·Journal of Diabetes Science and Technology·Alexander D McHughPaul D Docherty
Jan 23, 2021·Problemy e̊ndokrinologii·S A MartynovM V Shestakova
Feb 17, 2021·Journal of Diabetes Science and Technology·Jennifer J OrmsbeeTroy Merry
Jun 4, 2021·Journal of Diabetes Science and Technology·Anane YahiaBalazs Benyo
Jun 15, 2021·Therapeutic Advances in Endocrinology and Metabolism·Jennifer L KnoppGeoffrey M Shaw

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