PMID: 15361724Sep 14, 2004Paper

Impact of haemophilus influenzae type b conjugate vaccine in South Africa and Argentina

The Pediatric Infectious Disease Journal
Michael MartinDaniel R Feikin

Abstract

Haemophilus influenzae type b (Hib) persists as a major cause of pediatric meningitis and pneumonia in developing countries in which Hib conjugate vaccines are not used. Demonstration of decreases in severe Hib disease after countries introduce Hib conjugate vaccine will help justify the resources necessary to purchase and provide the vaccine. Because surveillance for culture-confirmed Hib meningitis is not available in many countries, alternative means to measure the impact of Hib conjugate vaccine would be useful. Laboratory records from the years before and after introduction of the Hib conjugate vaccine were reviewed at 4 hospitals, 2 in Argentina and 2 in South Africa. Potential indicators of bacterial meningitis including cerebrospinal fluid (CSF) culture, white blood cell count, appearance, protein and glucose were recorded. After introduction of Hib conjugate vaccine, culture-confirmed Hib meningitis declined significantly at 3 of 4 hospitals (2 in Argentina and 1 in South Africa). In the same 3 hospitals, there was a significant decline after vaccine introduction in some of the following CSF indicators of bacterial meningitis: proportion of CSF specimens with white blood cell count > or = 100 x 10(6)/L, 500 x 10(6)/L a...Continue Reading

References

May 1, 1991·Reviews of Infectious Diseases·A FunkhouserJ Ward
Aug 1, 1987·The Pediatric Infectious Disease Journal·C V Broome
Jan 13, 1993·JAMA : the Journal of the American Medical Association·W G AdamsJ D Wenger
Oct 19, 2000·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·C I AgudeloF De la Hoz
Dec 12, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H Peltola
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J H RexJ E Edwards
Nov 29, 2001·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·S A MadhiK P Klugman
Oct 3, 2003·The New England Journal of Medicine·Keith P KlugmanUNKNOWN Vaccine Trialists Group

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Citations

Apr 4, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S AfifiF Mahoney
Sep 18, 2012·Archives of Disease in Childhood·Simon Nadel
Oct 6, 2012·Annals of Clinical Microbiology and Antimicrobials·Michael OwusuYaw Adu-Sarkodie
Oct 18, 2011·Paediatric Drugs·Shruti Agrawal, Simon Nadel
Aug 30, 2008·Annals of Tropical Paediatrics·R IrisoA Kisayke
Apr 10, 2008·Tropical Medicine & International Health : TM & IH·Anna RocaPedro L Alonso
Jan 16, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Ahmet ArvasBekir Kocazeybek
Jun 1, 2005·Pediatric Clinics of North America·Susana Chávez-Bueno, George H McCracken
May 19, 2012·Paediatrics and International Child Health·Anushua SinhaKeith P Klugman
Feb 9, 2017·PloS One·Hamidreza HouriRamin Pouriran
Jun 28, 2008·The Lancet Infectious Diseases·Shaun K MorrisNeal Halsey

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