Impact of health technology assessment on prescribing patterns of inhaled fixed-dose combination triple therapy in chronic obstructive pulmonary disease.

Journal of Market Access & Health Policy
Jennifer CookSue Langham

Abstract

Background: Evidence suggests that triple therapy for patients with chronic obstructive pulmonary disease (COPD) is being used in a broader range of patients than recommended by guidelines, which may have health and cost implications. Objective: To explore the relationship between national health technology assessment (HTA) agency appraisals and market penetration of two fixed-dose combination (FDC) triple therapies. Study design: HTAs from Q3 2017 to Q1 2020 from 10 countries were evaluated. Intervention: Glycopyrronium bromide/formoterol fumarate/beclomethasone (Trimbow®) and umeclidinium/vilanterol/fluticasone furoate (Trelegy™ Ellipta®). Main outcome measure: HTA restrictions and prescribing rates (days of therapy). Results: Seven countries (70%) imposed restrictions on use including prescription only for patients stable on free-combination triple therapy or not controlled on dual therapy, requirement of a specialist prescription or therapeutic plan, prescription only for patients with severe COPD, and use as second-line therapy or later. In general, countries that have imposed restrictions on the use of FDC triple therapies have seen a lower than average uptake. Conclusion: Payer guidance on prescribing FDC triple therapy ...Continue Reading

References

Jan 14, 2016·Respiratory Medicine·Miriam BarrechegurenMarc Miravitlles
Jan 6, 2017·International Journal of Chronic Obstructive Pulmonary Disease·Jason C SimeoneTeresa K Wilcox
Dec 13, 2017·European Clinical Respiratory Journal·Josefin SundhChrister Janson
Aug 14, 2018·International Journal of Chronic Obstructive Pulmonary Disease·Jose Luis Lopez-CamposMyriam Calle Rubio
Aug 28, 2018·International Journal of Chronic Obstructive Pulmonary Disease·Giuseppe Antonio PalmiottiMaria Pia Foschino Barbaro
Oct 13, 2018·The European Respiratory Journal·Mario CazzolaMaria Gabriella Matera
Dec 1, 2018·International Journal of Chronic Obstructive Pulmonary Disease·José Luis Izquierdo, Borja G Cosio
Feb 19, 2019·International Journal of Chronic Obstructive Pulmonary Disease·Chloe I BloomJ K Quint

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IQVIA
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