Impact of Healthy Aging on Multifractal Hemodynamic Fluctuations in the Human Prefrontal Cortex

Frontiers in Physiology
Peter MukliAndras Eke

Abstract

Fluctuations in resting-state cerebral hemodynamics show scale-free behavior over two distinct scaling ranges. Changes in such bimodal (multi) fractal pattern give insight to altered cerebrovascular or neural function. Our main goal was to assess the distribution of local scale-free properties characterizing cerebral hemodynamics and to disentangle the influence of aging on these multifractal parameters. To this end, we obtained extended resting-state records (N = 214) of oxyhemoglobin (HbO), deoxyhemoglobin (HbR) and total hemoglobin (HbT) concentration time series with continuous-wave near-infrared spectroscopy technology from the brain cortex. 52 healthy volunteers were enrolled in this study: 24 young (30.6 ± 8.2 years), and 28 elderly (60.5 ± 12.0 years) subjects. Using screening tests on power-law, multifractal noise, and shuffled data sets we evaluated the presence of true multifractal hemodynamics reflecting long-range correlation (LRC). Subsequently, scaling-range adaptive bimodal signal summation conversion (SSC) was performed based on standard deviation (σ) of signal windows across a range of temporal scales (s). Building on moments of different order (q) of the measure, σ(s), multifractal SSC yielded generalized Hur...Continue Reading

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Citations

Mar 19, 2019·Frontiers in Physiology·Paolo Castiglioni, Andrea Faini
Sep 14, 2019·Brain Structure & Function·F Konrad SchumacherChristoph P Kaller
Dec 18, 2018·Frontiers in Physiology·Frigyes Samuel RaczAndras Eke
Feb 5, 2021·Brain and Behavior·Frigyes Samuel RaczAndras Eke

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Methods Mentioned

BETA
NIRS

Software Mentioned

SSC
Matlab
rsNIRS
StatSoft Statistica
FMF
MultiFracTool
AnCova

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