Impact of Helicobacter pylori colonization on immunoreactive epidermal growth factor and transforming growth factor-alpha in gastric juice. Its potential pathogenetic implications

Digestive Diseases and Sciences
M MarcinkiewiczJ Sarosiek

Abstract

Epidermal growth factor (EGF), pivotal in mucosal protection, is partly degraded proteolytically at low pH in the gastric milieu; gastric acid secretion, on the other hand, remains influenced by H. pylori colonization. The aim of this study, therefore, was to evaluate the impact of low pH and H. pylori colonization status on immunoreactive EGF and the other member of EGF-family, immunoreactive transforming growth factor-alpha (TGF-alpha). Eighteen patients with nonulcer dyspepsia (NUD) colonized by H. pylori and 55 NUD patients without H. pylori colonization were investigated. Gastric juice samples were aspirated at the beginning of the endoscopy procedure and immediately placed on ice, and their pH was recorded. The measurement of immunoreactive EGF and TGF-alpha was performed using commercially available radioimmunoassays (RIAs) after adjustment of pH to neutral using an assay buffer. Statistical analysis was performed using sigma-Stat for Windows. The concentration of immunoreactive EGF in patients with NUD colonized by H. pylori was 80% lower (P < 0.02) than in those without H. pylori and in both groups immunoreactive EGF was significantly lower when the pH of gastric juice was below 4.0. The concentration of immunoreactive...Continue Reading

References

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Citations

Dec 10, 1999·Immunopharmacology and Immunotoxicology·A Di LeoE Jirillo
May 16, 2000·The American Journal of Gastroenterology·J SarosiekJ R Pisegna
Sep 24, 2005·Digestion·Yuji NaitoHidekazu Suzuki
Oct 27, 1998·Current Medical Research and Opinion·M MarcinkiewiczE Czyzewska
Sep 4, 2001·Biotechnology & Genetic Engineering Reviews·W R WongJ Hackett

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