PMID: 11328266May 1, 2001Paper

Impact of Helicobacter pylori resistance to clarithromycin on the efficacy of the omeprazole-amoxicillin-clarithromycin therapy

Alimentary Pharmacology & Therapeutics
J TankovicJ C Delchier

Abstract

Helicobacter pylori resistance to clarithromycin is relatively frequent in France and is assumed to be the main cause of failure of the proton pump inhibitor-amoxicillin-clarithromycin (proton pump inhibitor-AC) therapy, which is the first-line regimen in France. To determine the respective effects of clarithromycin primary and secondary resistances on efficacy of the proton pump inhibitor-AC regimen and to determine whether failures are associated with persistence of the same strain or with emergence of a new one. A total of 123 H. pylori-infected patients were treated for 7 days with omeprazole 20 mg b.d., amoxicillin 1 g b.d., and clarithromycin 500 mg b.d. Eradication was assessed by breath test in 102 patients. Minimal inhibitory concentrations of clarithromycin were determined by E-test. Strain genotyping was performed by random amplified polymorphic DNA. The pre-treatment and post-treatment prevalences of clarithromycin resistance were 19% (23 out of 123) and 69% (nine out of 13), respectively. The rates of eradication were 68% (69 out of 102), 79% (67 out of 85), and 12% (two out of 17) for all, susceptible and resistant strains, respectively. The post-treatment isolate was available for six patients with a susceptible ...Continue Reading

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Citations

Oct 22, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S Toracchio, L Marzio
Mar 6, 2002·Alimentary Pharmacology & Therapeutics·S Di CaroA Gasbarrini
Aug 29, 2002·Helicobacter·Franco BazzoliTheodore Rokkas
Sep 18, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Wai Man WongBenjamin Chun-Yu Wong
May 11, 2002·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·B GrignonJ L Fauchère
Nov 5, 2013·Clinical Interventions in Aging·Raymond S Y Tang, Justin C Y Wu
Aug 8, 2012·Drugs·Raymond S Tang, Francis K L Chan
Jan 2, 2008·Gastroentérologie Clinique Et Biologique·Jacques TankovicJean-Charles Delchier
Dec 23, 2003·Journal of Internal Medicine·V OjettiA Gasbarrini
Oct 11, 2003·Alimentary Pharmacology & Therapeutics·H LamouliatteUNKNOWN Multicentre Study Group
Sep 1, 2007·Helicobacter·Leonardo Garrido, Hector Toledo
Aug 21, 2013·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Nahla A MelakeMagdy A Salama
Mar 12, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E RimbaraM Sasatsu
Jul 5, 2007·The American Journal of Gastroenterology·William D CheyUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
May 27, 2004·World Journal of Gastroenterology : WJG·Engin AltintasHandan Camdeviren
Oct 3, 2003·Hospital Medicine·Craig Williams
Jul 28, 2019·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Julio Valle MuñozRafael Gómez Rodríguez

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