Impact of helminth infection during pregnancy on cognitive and motor functions of one-year-old children

PLoS Neglected Tropical Diseases
Michael O MirekuFlorence Bodeau-Livinec

Abstract

To determine the effect of helminth infection during pregnancy on the cognitive and motor functions of one-year-old children. Six hundred and thirty five singletons born to pregnant women enrolled before 29 weeks of gestation in a trial comparing two intermittent preventive treatments for malaria were assessed for cognitive and motor functions using the Mullen Scales of Early Learning, in the TOVI study, at twelve months of age in the district of Allada in Benin. Stool samples of pregnant women were collected at recruitment, second antenatal care (ANC) visit (at least one month after recruitment) and just before delivery, and were tested for helminths using the Kato-Katz technique. All pregnant women were administered a total of 600 mg of mebendazole (100 mg two times daily for 3 days) to be taken after the first ANC visit. The intake was not directly observed. Prevalence of helminth infection was 11.5%, 7.5% and 3.0% at first ANC visit, second ANC visit and at delivery, respectively. Children of mothers who were infected with hookworms at the first ANC visit had 4.9 (95% CI: 1.3-8.6) lower mean gross motor scores compared to those whose mothers were not infected with hookworms at the first ANC visit, in the adjusted model. Hel...Continue Reading

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Citations

Sep 8, 2015·Metabolic Brain Disease·Emmanuel Quansah, Thomas K Karikari
Mar 5, 2016·Applied & Translational Genomics·Thomas K Karikari, Jelena Aleksic
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Jun 8, 2018·Tropical Medicine & International Health : TM & IH·Michael O MirekuFlorence Bodeau-Livinec
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Feb 13, 2016·PloS One·Violeta Moya-AlvarezFlorence Bodeau-Livinec
Jan 10, 2019·International Journal of Environmental Research and Public Health·Kei OwadaRicardo J Soares Magalhães
Mar 5, 2020·Journal of Tropical Pediatrics·Michael O MirekuFlorence Bodeau-Livinec
Jan 9, 2016·PloS One·Emmanuel QuansahThomas K Karikari
Feb 21, 2018·The Journal of Infectious Diseases·Paul R GiacominRicardo J Soares Magalhães
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Jul 24, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Amanda GarrisonFlorence Bodeau-Livinec
Jun 10, 2015·Pediatrics·Michael O MirekuFlorence Bodeau-Livinec

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Clinical Trials Mentioned

NCT00811421

Software Mentioned

Stata IC /

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