Impact of hemoglobin levels on hemoglobin-adjusted carbon monoxide diffusion capacity after chemotherapy for testicular cancer

Japanese Journal of Clinical Oncology
Satoshi NittaHiroyuki Nishiyama

Abstract

We aimed to compare the diffusion capacity of carbon monoxide (DLCO), which was adjusted using the two equations the Cotes method and the Dinakara method, to assess bleomycin-induced lung injury in testicular cancer patients preparing for post-chemotherapy surgery. Between November 1990 and October 2018, 89 patients with advanced testicular cancer were recruited into the study. All patients received chemotherapy and underwent DLCO measurements using the single-breath technique prior to surgery for residual tumor removal. The mean DLCO adjusted for hemoglobin using the Cotes and Dinakara methods was 69.5% and 86.0%, respectively (P < 0.001). According to the Cotes method, adjusted DLCO was severely diminished to below 65% in 40 patients (45%), whereas this proportion was only 16% according to the Dinakara method. We observed a significant correlation between hemoglobin levels and DLCO adjusted using the Cotes method (P < 0.001), but not using the Dinakara method. Four patients received a clinical diagnosis of bleomycin-induced pneumonitis (BIP), and all patients recovered after oral steroid therapy or observation. The DLCO adjusted by either methods was not well correlated with the development of BIP. No patients had major posto...Continue Reading

References

Jun 1, 1978·Clinical Science and Molecular Medicine·E H ClarkJ M Hughes
May 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M J McKeageP J Dady
Apr 1, 1985·Australian and New Zealand Journal of Medicine·M R BellP G Gill
Jun 4, 1987·The New England Journal of Medicine·S D WilliamsP J Loehrer
Mar 1, 1995·The Journal of Urology·J BanielJ P Donohue
Jan 1, 1997·American Journal of Respiratory and Critical Care Medicine·R M MarradesR Rodriguez-Roisin
Dec 19, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J M O'SullivanA Horwich
Oct 6, 2005·The European Respiratory Journal·N MacintyreJ Wanger
Jan 15, 2013·Critical Reviews in Oncology/hematology·Marios FroudarakisEvangelos Briasoulis
Nov 20, 2014·The New England Journal of Medicine·Nasser H Hanna, Lawrence H Einhorn
Jun 16, 2016·Internal Medicine Journal·F T RoncolatoUNKNOWN Australian and New Zealand Urogenital Prostate Cancer Trials Group (ANZUP)
Jan 4, 2017·The European Respiratory Journal·Brian L GrahamJack Wanger
Aug 30, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adam C CalawayClint Cary

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.