Impact of Hepatic Steatosis on the Antiviral Effects of PEG-IFNα -2a in Patients with Chronic Hepatitis B and the Associated Mechanism

Gastroenterology Research and Practice
Huiqing LiangShaodong Chen

Abstract

To investigate the risk factors for hepatic steatosis in chronic hepatitis B (CHB), to determine its correlation with liver necroinflammation and fibrosis and response to peginterferon alpha-2a (PEG-IFNα-2a) antiviral therapy, and to explore the mechanisms underlying the poor antiviral effect of PEG-IFNα-2a in CHB patients with hepatic steatosis. We analysed the impact of hepatic steatosis on the antiviral effect of PEG-IFNα-2a on CHB patients in a cohort of 226 patients who underwent pretherapeutic liver biopsy. To assess the complete response (CR), virological response (VR), and biochemical response (BR), the 226 patients were treated with PEG-IFNα-2a for 48 weeks and were followed-up for 24 weeks. The expressions of hepatitis B surface antigen (HBsAg) and hepatitis B core antigen (HBcAg) in the liver tissue were detected in all patients to explore the possible mechanism of hepatic steatosis with regard to antiviral effects. The patients were divided into four groups based on the severity of hepatic steatosis: 119 with no steatosis, 76 with mild steatosis, 22 with moderate steatosis, and 9 with severe steatosis. In the hepatic steatosis groups, the proportions of male patients, patients aged >40 years, patients with hyperuric...Continue Reading

References

May 27, 2005·World Journal of Gastroenterology : WJG·Emin AltlparmakTulin Sahin
Apr 12, 2016·Clinics in Liver Disease·Andrea MarengoElisabetta Bugianesi
Jun 17, 2016·Revista da Associação Médica Brasileira·Gabriel Costa de AndradeRita de Cássia Martins Alves da Silva
Jul 28, 2016·The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology·Emine KöroğluHakan Şentürk
Jul 28, 2016·The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology·Zehra Karacaer
Jun 24, 2017·Journal of Hepatology·Jian-Gao FanVincent Wai-Sun Wong

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Methods Mentioned

BETA
biopsy
biopsies
PCR
dot blot

Software Mentioned

SPSS

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