Impact of hepatitis C virus (HCV) antiviral treatment on the need for liver transplantation (LT)

Liver International : Official Journal of the International Association for the Study of the Liver
Esteban Sáez-GonzálezMarina Berenguer

Abstract

Therapies for hepatitis C virus (HCV) infection have revolutionized the treatment of patients with chronic HCV infection. The effect of these therapies on the epidemiology of liver transplantation (LT) has yet to be elucidated. To establish whether the indications for LT have changed as a result of the introduction of new therapies for HCV. We conducted a retrospective study based on a prospectively maintained registry of patients who undergo LT at La Fe Hospital in Valencia from 1997 to 2016. An analysis of outcome measures over time stratified by LT indications was performed. From January 1997 to December 2016, 2379 patients were listed for LT. Of these, 1113 (47%) were listed for HCV cirrhosis±hepatocellular carcinoma (HCC). This percentage varied significantly over time declining from 48.8% in the 1997-2009 initial period (IFN-based regimens) to 33% in the 2014-2016 final period (DAAs regimens) (P = .03). However, during that period, the proportion of those included in the waiting list (WL) due to HCV-HCC increased significantly (P = .001). In addition, among HCV-positive waitlisted patients with decompensated cirrhosis without HCC, the proportion of those with an HCV-alcohol mixed etiology also increased significantly over...Continue Reading

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Citations

Mar 12, 2019·Expert Review of Anti-infective Therapy·Lai Wei, Yi-Hsiang Huang
Feb 21, 2019·Arquivos De Gastroenterologia·Edna Strauss
Oct 1, 2020·World Journal of Transplantation·Danko Mikulic, Anna Mrzljak
Dec 24, 2018·Journal of Hepatology·François DurandClaire Francoz
May 1, 2021·Clinics and Research in Hepatology and Gastroenterology·Ekaterina A NabatchikovaSergey V Moiseev
May 20, 2021·World Journal of Gastroenterology : WJG·Mohamed ShengirGiada Sebastiani
Jun 7, 2021·European Journal of Gastroenterology & Hepatology·Ceren Atasoy TahtasakalIlyas Dokmetas

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