Impact of hepatitis C virus infection on clinical features, quality of life and survival of patients with lymphoplasmacytoid lymphoma/immunocytoma

Annals of Oncology : Official Journal of the European Society for Medical Oncology
F SilvestriM Baccarani

Abstract

The non-Hodgkin's lymphoma (NHL) subgroup most frequently associated with hepatitis C virus (HCV) infection is the lymphoplasmacytoid lymphoma/immunocytoma (Lp-Ic). We have assessed the impact of the infection on the clinical features, quality of life and survival of HCV+ve Lp-Ic patients as compared to its impact in HCV-ve patients. Seventy patients with Lp-Ic consecutively observed over a six-year period were studied. Clinical, virological and histopathological features were recorded at diagnosis. Quality of life was assessed using a scoring system including disease-related symptoms, performance status, working ability, hospital admissions and therapies required. Eighteen patients (26%) with HCV infection were identified. Significant differences between those patients and the HCV-ve group included number of symptomatic patients, Hb levels, serum protein levels, entity of the IgM monoclonal component, number of patients with cryoglobulins and with organ (liver, kidney) involvement, and entity and pattern of bone marrow infiltration. Survival rates were similar (P = 0.8383), but the quality-of-life score was significantly worse for the HCV+ve patients (P = 0.002). All anti-HCV Ab+ve patients tested positive for HCV RNA; genotyp...Continue Reading

Citations

Mar 18, 2005·Alimentary Pharmacology & Therapeutics·J P GisbertR Moreno-Otero
Mar 1, 2007·Expert Review of Clinical Immunology·Ellis KingJonathan P Moorman
Mar 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yasuharu ImaiYuji Matszawa
Jan 10, 2003·The New England Journal of Medicine·Sylvie HermouetJames W Casey
Jan 29, 2008·European Journal of Haematology·Omer DizdarIbrahim Barista
Dec 21, 2000·Current Oncology Reports·F SilvestriR Fanin
Jul 13, 2002·Journal of Medical Virology·Dominique ChallineJean-Marie Seigneurin
May 1, 2008·International Journal of Hematology·Pierluigi CoccoAlexandra Nieters
Sep 18, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G GermanidisJ M Pawlotsky
Jul 27, 2006·International Urology and Nephrology·A N AravindanVivekanand Jha
Sep 24, 2014·Case Reports in Oncological Medicine·Ryan NippAra Metjian
Aug 4, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A L ZignegoUNKNOWN Italian Association of the Study of Liver Commission on Extrahepatic Manifestations of HCV infection

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.