Impact of high dietary zinc on zinc accumulation, enzyme activity and proteomic profiles in the pancreas of piglets

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Robert PieperAngelika Bondzio

Abstract

The exocrine pancreas plays an important role in zinc homeostasis. Feeding very high (2000-3000mgzinc/kg diet) levels of zinc oxide to piglets for short periods is a common practice in the swine industry to improve performance and prevent diseases. The impact on pancreatic function and possible side effects during long-term feeding of high dietary zinc levels are still poorly understood. A total of 54 weaned piglets were either fed with low (57mg/kg, LZn), normal (164mg/kg, NZn) or high (2425mg/kg, HZn) zinc concentration in the diets. After 4 weeks of feeding, ten piglets per treatment were euthanized and pancreas samples were taken. Tissue zinc concentration and metallothionein abundance was greater with HZn compared with NZn and LZn (P<0.05). Similarly, activity of α-amylase, lipase, trypsin and chymotrypsin was higher with HZn as compared with NZn and LZn diets (P<0.05), whereas elastase activity was unchanged. Total trolox equivalent antioxidative capacity of pancreas tissue was higher with HZn diets compared with the other treatments (P<0.05). Pancreatic protein profiles of NZn and HZn fed piglets were obtained by 2D-DIGE technique and revealed 15 differentially expressed proteins out of 2100 detected spots (P<0.05). The ...Continue Reading

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Citations

Apr 7, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·A ZetzscheR Pieper
Jun 11, 2016·Journal of Animal Science·E-J BosF A M Tuyttens
Jun 19, 2019·Asian-Australasian Journal of Animal Sciences·Gang ZhangLiying Zhang
Jan 7, 2019·Biological Trace Element Research·Gretchen Myers Hill, Marcia Carlson Shannon
Dec 19, 2019·Frontiers in Microbiology·Vanessa C JohannsLothar H Wieler
Jul 28, 2020·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Tetsuya KomatsuTomoyuki Shibahara
Dec 31, 2020·Animals : an Open Access Journal From MDPI·Fen-Fen LiuHeng-Jia Ni
May 3, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Maoqing WangFan Wang

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