Impact of high-dose vitamin D3 on plasma free 25-hydroxyvitamin D concentrations and antimicrobial peptides in critically ill mechanically ventilated adults

Nutrition
Jenny E HanThomas R Ziegler

Abstract

High-dose vitamin D3 increases plasma total 25-hydroxyvitamin D [25(OH)D] in critically ill, ventilated patients; however, to our knowledge, the effect on plasma levels of free (nonprotein-bound) 25(OH)D has not been investigated in critical illness. Moreover, the relationship of free 25(OH)D and the regulation of endogenous antimicrobial peptides (AMPs) remains unknown. The aims of this study were to determine in critically ill adults with respiratory failure the effect of previous high-dose regimens of vitamin D3 on free 25(OH)D concentrations, the relationship of free 25(OH)D with circulating cathelicidin (LL-37) and human beta-defensin-2 (hBD-2), and the associations between plasma levels of free 25(OH)D and these AMPs to alveolar macrophage phagocytosis function. In a double blind, randomized controlled trial, critically ill ventilator-dependent adults (N = 30) received enteral vitamin D3 (250,000 or 500,000 IU total over 5 d) or placebo. Plasma was obtained serially for concentrations of free 25(OH)D, LL-37, hBD-2, and expression of peripheral blood mononuclear cell human cationic antimicrobial protein (hCAP18) mRNA. Total 25(OH)D and LL-37 concentrations and alveolar macrophage phagocytosis were determined in bronchoalve...Continue Reading

Citations

Jun 23, 2018·The Journal of Clinical Endocrinology and Metabolism·Albert ShiehJohn S Adams
Feb 28, 2019·PloS One·Robert M BurkesM Bradley Drummond
Jul 17, 2020·Frontiers in Public Health·Mardi A Crane-GodreauSteven Fiering
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Sandra Maria BarbalhoMarcelo Dib Bechara
Jul 17, 2020·Archives of Oral Biology·Batuhan A BayirliBahattin Avci
Aug 10, 2021·Nutrition Research Reviews·Inez SchoenmakersAlastair Forbes

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