Impact of high iron intake on cognition and neurodegeneration in humans and in animal models: a systematic review

Nutrition Reviews
Sonal AgrawalJonathan H Fox

Abstract

Accumulation of brain iron is linked to aging and protein-misfolding neurodegenerative diseases. High iron intake may influence important brain health outcomes in later life. The aim of this systematic review was to examine evidence from animal and human studies of the effects of high iron intake or peripheral iron status on adult cognition, brain aging, and neurodegeneration. MEDLINE, Scopus, CAB Abstracts, the Cochrane Central Register of Clinical Trials, and OpenGrey databases were searched. Studies investigating the effect of elevated iron intake at all postnatal life stages in mammalian models and humans on measures of adult brain health were included. Data were extracted and evaluated by two authors independently, with discrepancies resolved by discussion. Neurodegenerative disease diagnosis and/or behavioral/cognitive, biochemical, and brain morphologic findings were used to study the effects of iron intake or peripheral iron status on brain health. Risk of bias was assessed for animal and human studies. PRISMA guidelines for reporting systematic reviews were followed. Thirty-four preclinical and 14 clinical studies were identified from database searches. Thirty-three preclinical studies provided evidence supporting an a...Continue Reading

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Citations

Sep 1, 2017·Current Genetics·Brett T WisniewskiAnita L Manogaran
Aug 30, 2019·Nutrition Journal·Zumin ShiJianghong Liu
Apr 25, 2020·Mechanisms of Ageing and Development·Alfonso SchiaviNatascia Ventura
Apr 11, 2020·Cell Chemical Biology·Annadurai AnandhanDonna D Zhang
Dec 21, 2021·Nutritional Neuroscience·Patricia L EastSheila Gahagan

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