Nov 3, 2004

Impact of HLA-identity on results of ABO-incompatible living kidney transplantation

Transplantation Proceedings
H ShimmuraH Toma

Abstract

Due to the continuing shortage of cadaveric donors in Japan, ABO-incompatible living kidney transplantation is being performed. Our previous studies showed that the long-term graft survival in ABO-incompatible living kidney transplantation was comparable to that in ABO-compatible living kidney transplantation. However, the impact on HLA-identity on the results of ABO-incompatible living donor kidney transplantation had not been investigated previously. One hundred twenty-seven recipients underwent ABO-incompatible living kidney transplantation between January 1989 and December 2000. Five were grafted from HLA-identical sibling donors group (I). The remaining 122 recipients received grafts from an HLA-nonidentical donor (group N). Both groups were similar in terms of recipient age, donor age, warm ischemic time, and total ischemic time. Three or four sessions of plasmapheresis were performed prior to transplantation. Cyclosporine or tacrolimus, methylprednisolone, and azathioprine or mycophenolate mofetil were used for immunosuppression. Splenectomy was done at the time of kidney transplantation in all patients. Graft loss was seen in one of the five HLA-identical recipients due to chronic rejection. Five- and 10-year graft surv...Continue Reading

  • References1
  • Citations3

References

  • References1
  • Citations3

Citations

Mentioned in this Paper

Decreased Immunologic Activity [PE]
Sister
Pancreatitis, Graft
Blood Group H Type 1 Antigen
Mycophenolate mofetil
Cyclosporine
Graft Survival
Survival Analysis
Kidney
Tacrolimus

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