PMID: 3213235Jan 1, 1988Paper

Impact of hormonal prevention on fractures of the proximal femur in postmenopausal women: a simulation study

Sozial- Und Präventivmedizin
M Van der LoosR Chrzanowski

Abstract

A simulation model of the effects of hormone replacement therapy (HRT) on hip fractures and their consequences is based on a population of 100,000 post-menopausal women. This cohort is confronted with literature derived probabilities of cancers (endometrium or breast, which are contra-indications to HRT), hip fracture, disability requiring nursing home or home care, and death. Administration of HRT for life prevents 55.5% of hip fractures, 22.6% of years with home care and 4.4% of years in nursing homes. If HRT is administered for 15 years, these results are 15.5%, 10% and 2.2%, respectively. A slight gain in life expectancy is observed for both durations of HRT. The net financial loss in the simulated population is 222 million Swiss Francs (cost/benefit ratio 1.25) for lifelong administration of HRT, and 153 million Swiss Francs (cost/benefit ratio 1.42) if HRT is administered during 15 years.

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Citations

Nov 18, 2000·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·A CranneyP Tugwell

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