Abstract
Children undergoing hematopoietic stem cell transplant (HSCT) are prone to infections, especially when hospitalized for the transplant or additional medical care. These infections are perceived to increase patient's mortality risk, but data are lacking. We conducted this study to assess the burden and the impact of hospital acquired infections (HAI) on mortality risk among pediatric HSCT patients. This retrospective study included 169 patients that received allogeneic HSCT between January 1 2011 and July 6 2017 at Children's National Hospital, a tertiary referral center. Clinical and laboratory data were reviewed for 1 year after transplant to determine HAI and survival status. The HAI incident rates stratified by bloodstream, respiratory, and gastrointestinal infections were then compared between deceased patients and survivors. Including transplant, 169 patients sustained 499 hospital admissions for total of 10,523 patient days and 112 HAI episodes, resulting in a HAI rate of 10.6 per 1,000 patient-days. Within 1-year after transplant, 38 (22%) patient died, 30 (17.5%) with nonrelapse-related causes. Unadjusted univariate analysis revealed mortality correlated with cell source (p=0.035), donor type (p = 0.002), respiratory vi...Continue Reading
References
Oct 9, 2002·Journal of Virology·C T GarnettLinda R Gooding
Aug 2, 2007·Haematologica·Marie RobinGérard Socié
Sep 15, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Marcie TomblynUNKNOWN Centers for Disease Control and Prevention
Oct 29, 2009·Bone Marrow Transplantation·D YokoeUNKNOWN Centers for Disease Control and Prevention
Sep 15, 2010·Blood·Caroline A LindemansJaap Jan Boelens
Dec 22, 2011·Infection·M MikulskaC Viscoli
May 15, 2013·Hematology/oncology and Stem Cell Therapy·Walid RasheedMahmoud Aljurf
Jan 1, 2014·Transplant Infectious Disease : an Official Journal of the Transplantation Society·O BlennowM Remberger
Oct 24, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Jan StyczynskiUNKNOWN Polish Society of Paediatric Oncology and Haematology
Dec 8, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Elena BeamRaymund R Razonable
Dec 30, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K KosulinT Lion
Jun 28, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Ugur SahinTaner Demirer
Aug 3, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anthony D SungMitchell E Horwitz
Sep 16, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Kelsey A SokolAmir Steinberg
Jul 1, 2017·Current Opinion in Infectious Diseases·Yeon Joo LeeGenovefa A Papanicolaou
Oct 28, 2017·Frontiers in Immunology·Amy Houghtelin, Catherine M Bollard
Nov 7, 2017·Journal of the Pediatric Infectious Diseases Society·Brian T FisherWilliam J Steinbach
Mar 14, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Starling A SimBenjamin W Teh
Apr 9, 2018·Infection·Saira AjmalM Rizwan Sohail
May 29, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·José Luis PiñanaDavid Navarro
Dec 14, 2018·Bone Marrow Transplantation·Celalettin UstunMarcie Riches